2023年10月14日 · 瘤内dc既能向传入的T细胞提供生存信号，又能驱动效应分化，从而局部增强抗肿瘤免疫;然而，体内 DCs 的缺乏或其免疫调节分子的表达往往限制了抗肿瘤T细胞的反应。

T淋巴细胞又根据其表面表达的特异性抗原不同，分为CD4+T淋巴细胞和CD8+T淋巴细胞。 CD4+主要由辅助T（Th）细胞表达，是Th细胞TCR识别抗原的受…

2020年5月20日 · Migratory dendritic cells integrate signals from antigen and bystander cells to inform CD4+ T cell differentiation in local lymph nodes. a Migratory DC (migDC) sample antigen in non-lymphoid...

Classical dendritic (cDC) cell stimulation of CD4+ T cells and CD8+ T cells. Activated classical dendritic cells (cDCs) travel to the T cell areas of secondary lymphoid tissues to stimulate CD4+ T cells through classical antigen presentation on MHC class II. cDCs can also stimulate CD8+ T cells through classical and cross-presentation pathways.

Dendritic cells (DC) are a class of bone‐marrow‐derived cells arising from lympho‐myeloid haematopoiesis that form an essential interface between the innate sensing of pathogens and the activation of adaptive immunity.

cDC2细胞具有一般DC家族的功能，通过MHC II类抗原呈递以及共刺激活化Naive CD4 + T细胞。 cDC1细胞专门用于交叉提呈，或在MHC I类上提呈外源抗原，以诱导Naive CD8 + T细胞分化并激活 [7]。

2023年6月15日 · Response to anti-PD-1 in patients with hepatocellular carcinoma is associated with clonal expansion of intratumoral CXCL13+ CD4+ helper T cells and effector-like CD8+ T cells, and local dendritic...

2024年7月25日 · Adjuvants known as hyperactivators can correct age-associated defects in dendritic cells, enabling anti-tumor T cell responses in old and young mice. The protective immunity elicited by hyperactive dendritic cells is driven by CD8+ T cells in young mice but directed by cytolytic CD4+ T cells in elderly mice.

2024年2月5日 · 关于树突状细胞（DC）与CD4+T细胞共培养的问题： 1.T细胞在加入DC细胞后，是否一定要加入CD3,CD28抗体？ 抗体是和T细胞同时加进去，还是提前包被到dish上? 2.如果需要包被的话，用什么buffer包被？ 包被多久？

Infection of dendritic cells (DC) by human immunodeficiency virus (HIV) has been disputed. Employing a fluorescence-activated cell sorter, DC, identified by the absence of membrane markers for T, B, natural killer (NK) and monocytic cells and by high levels of MHC class II DR antigen, were shown to …