Antigen presentation by dendritic cells and their instruction of CD4…
2020年5月20日 · Signals from pathogens, immunogens, and antigens, as well as signals from the local stromal, epithelial, and immune cells influence DC expression of CD4+ T cell polarizing …
Immunity | 树突状细胞(DCs)在肿瘤中作为T细胞免疫的"牧羊人"
2023年10月14日 · 在癌症患者中，肿瘤引流淋巴结中的 树突状细胞 (DCs)可以以破坏 免疫耐受 的方式向幼稚T细胞呈递抗原。 引物T细胞的克隆扩增后代进一步受到肿瘤部位 DCs 的调控。 …
CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell ...
2025年2月26日 · Here, we show that in mice, CD301b+ DCs, a major Th2-inducing DC subset, drive Th2 differentiation through cognate interaction by rapidly inducing IL-2 receptor signalling …
The role of CD40 and CD40L in Dendritic Cells - PMC
In this review, we focus on the function of CD40-CD40L (CD154) interactions in the regulation of dendritic cell (DC) - T cell and DC-B cell cross-talk. In addition, we examine differences and …
Proximity-dependent labeling identifies dendritic cells that drive …
2024年10月4日 · Using LIPSTIC (Labeling Immune Partnerships by SorTagging Intercellular Contacts)–based single-cell transcriptomics, we identified individual DCs capable of …
Coculture of Human Dendritic and T Cells for the Study of
2023年9月23日 · Dendritic cells (DCs) connect innate and adaptive immunity by sampling, capturing, processing, and presenting the allergen to distinct subsets of CD4 + T cells.
Intratumoral immune triads are required for immunotherapy …
2024年6月20日 · We demonstrate that CD4 + T cells mediate tumor-specific CD8 + T cell reprogramming within large solid tumors when tumor-reactive CD4 + and CD8 + T cells form …
Correction of age-associated defects in dendritic cells enables CD4
2024年6月12日 · Adjuvants known as hyperactivators can correct age-associated defects in dendritic cells, enabling anti-tumor T cell responses in old and young mice. The protective …
CD4 + helper T cells endow cDC1 with cancer-impeding functions …
2023年1月13日 · Despite their low abundance in the tumor microenvironment (TME), classical type 1 dendritic cells (cDC1) play a pivotal role in anti-cancer immunity, and their abundance …
Melanoma immunotherapy by nanosphere-vaccine elicited CD4
This vaccine elicits specific immune responses through bone marrow DC maturation and CD4+/CD8+ T-cell activation, targeting melanoma antigens. In preclinical studies using …