2025年2月10日 · We find that such a simple yet effective Light-DDG can serve as a good unsupervised antibody optimizer and explainer. For the target antibody, we propose a novel Mutation Explainer to learn mutation preferences, which accounts for the marginal benefit of each mutation per residue.

In this activity, you will utilize the Flex ddG protocol within Rosetta to computationally model and predict changes in binding free energies upon mutation (interface ΔΔG). This protocol uses the "backrub" protocol [CS2018]_ implemented in Rosetta to sample conformational diversity.

2023年7月31日 · Considering this phenomenon, we propose Discriminability-Driven Graph Network (DDG-Net), which explicitly models ambiguous snippets and discriminative snippets with well-designed connections, preventing the transmission of ambiguous information and enhancing the discriminability of snippet-level representations.

2022年5月27日 · Unfortunately, there is a lack of training-free mechanism to adjust the model when generalized to the agnostic target domains. To tackle this problem, we develop a brand-new DG variant, namely Dynamic Domain Generalization (DDG), in which the model learns to twist the network parameters to adapt the data from different domains.

2023年6月27日 · Flex ddG教程 该教程的最新版本。 介绍 在本活动中，您将利用Rosetta中的Flex ddG 协议对突变后的结合自由能（接口ΔΔG）进行计算建模和预测。 该协议使用“ backrub”协议在实现，以采样构象多样性。

2025年3月3日 · Background and Objectives: Generalized pustular psoriasis (GPP) is a rare, chronic, potentially life-threatening skin disease. We aimed to establish criteria to accurately approximate GPP prevalence in Germany. Methods: A retrospective analysis of the WIG2 health claims database (1/1/2016–31/12/2020) was conducted.

中塑在线提供abs dg-417/天津大沽物性表数据，了解abs dg-417/天津大沽材料状态、特性、用途、加工方法、形态、物理性能等物性参数。

2022年5月16日 · Das Hautmikrobiom etabliert sich unmittelbar nach der Geburt und spielt eine wichtige Rolle für die Entwicklung und Aufrechterhaltung einer Immunhomöostase. Das Krankheitsbild der atopischen Dermatitis ist unter anderem durch Veränderungen des Hautmikrobioms gekennzeichnet.

Die §§ 1, 2, 3, 4, 5, 6 und 23 dienen der Umsetzung der Richtlinie 2000/31/EG des Europäischen Parlaments und des Rates vom 8. Juni 2000 über bestimmte rechtliche Aspekte der Dienste der Informationsgesellschaft, insbesondere des elektronischen Geschäftsverkehrs, im Binnenmarkt („Richtlinie über den elektronischen Geschäftsverkehr“) (ABl.

In this activity, you will utilize the Flex ddG protocol within Rosetta to computationally model and predict changes in binding free energies upon mutation (interface ΔΔG). This protocol uses the "backrub" protocol [CS2018]_ implemented in Rosetta to sample conformational diversity.