In this study, we firstly reported DDR1 activation in macrophages to play a role in IPF via inflammasome activation and macrophage responses. In addition, DDR1 inhibitors DDR1-IN-1 and DDR1-IN-2 exerted significant anti-inflammatory and anti-fibrotic effects in IPF, all of which provide a potentiall …

2021年11月24日 · In this study we designed and synthesized a new indazole derivative XBLJ-13, and identified XBLJ-13 as a highly specific and potent DDRs inhibitor with anti-inflammation and anti-fibrosis...

2019年11月1日 · In normal lung, DDR1 is expressed in bronchiolar epithelial cells as well as in type 1 and 2 alveolar pneumocytes. In IPF, DDR1 retains the same expression patterns in bronchiolar and alveolar epithelia whereas no positivity is observed in myofibroblasts.

2022年12月1日 · DDR1 exacerbate IPF through mediating inflammasome synthesis, assembly and activation in bleomycin-induced IPF models. C57BL/6 mice were induced to IPF models and intervened with DDR1-specific inhibitors DDR1-IN-1, DDR1-IN-2 same as (Fig. 2).

2016年2月25日 · The results suggested the discoidin domain receptor 1 (DDR1) and downstream c-Jun N-terminal kinases (JNK) pathway may play important roles in the progression of IPF. To our knowledge, discoidin domain receptor 1 (DDR1) is a kind of receptor tyrosine kinase (RTK) with a unique ability to bind both fibrillar and non-fibrillar collagens.

2024年3月15日 · In the bleomycin (BLM)-induced rat model of idiopathic pulmonary fibrosis (IPF), compound 9 inhibited excessive collagen deposition and reduced airway inflammation. Additionally, the study suggested that the DDR1-mediated JNK signaling pathway might play an important role in the progression of IPF [ 105 ].

本研究建立了博来霉素诱导的 ipf 小鼠模型，并在体内给予两种 ddr1 抑制剂，以研究 ddr1 在 ipf 中的作用。 慢病毒介导的 DDR1 -/- 稳定的 Raw264.7 巨噬细胞系或 DDR1 抑制剂体外处理，以研究 DDR1 对炎性体激活和巨噬细胞反应的影响 。

Suppression of DDR1 expression in fibroblasts by siRNA abolished these effects, and an NF-kappaB inhibitor abrogated the anti-apoptotic effect of DDR1 activation. We propose that DDR1 contributes to fibroblast survival in the tissue microenvironment of IPF and that DDR1 up-regulation may occur in other fibroproliferative lung diseases as well.

As collagen deposition represents a key feature in fibrosis, the receptor tyrosine kinase Discoidin Domain Receptor1 (DDR1), which interacts and gets activated by collagens, was studied in IPF. It has been demonstrated that DDR1 inhibition suppresses the progression of bleomycin-induced pulmonary fibrosis and improves the survival rate.

2016年4月26日 · The results suggested the discoidin domain receptor 1 (DDR1) and downstream c-Jun N-terminal kinases (JNK) pathway may play important roles in the progression of IPF. To our knowledge, discoidin domain receptor 1 (DDR1) is a kind of receptor tyrosine kinase (RTK) with a unique ability to bind both fibrillar and non-fibrillar collagens.