DEAD-Box RNA Helicases and Genome Stability - MDPI
2021年9月23日 · DEAD-box RNA (DDX) helicases are characterized by the presence of a specific amino acid motif, Asp-Glu-Ala-Asp (DEAD). DDX helicases comprise highly conserved core …
DDX RNA helicases: key players in cellular homeostasis and innate ...
2024年8月30日 · DDX3X recognizes viral RNA and interacts with MAVS and TBK1, which phosphorylates IRF3/7 and DDX3; phosphorylated-DDX3 indirectly activates IFN-β …
Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X …
2018年9月26日 · Novel rG4 interactors included DDX3X, DDX5, DDX17, GRSF1 and NSUN5. The majority of identified proteins contained a glycine-arginine (GAR) domain and notably …
Kevin Raney (University of Arkansas) described the binding of yeast Ded1 (human homolog DDX3X) to G-quadruplex (G4) DNA, leaking from the nucleus or mitochondria, initiating LLPS …
DDX5 helicase resolves G-quadruplex and is involved in MYC gene ...
2019年10月8日 · The DDX5 interaction with the MYC promoter and DDX5-mediated MYC activation is inhibited by G4-interactive small molecules. Our results uncover a function of …
DDX3 regulates cancer immune surveillance via 3′ UTR-mediated …
2024年3月26日 · Here, we show that inhibition of the RNA helicase DDX3 increased CD8 + T cell infiltration in syngeneic oral squamous cell carcinoma tumors. DDX3 knockdown compromised …
Action and function of helicases on RNA G-quadruplexes
2022年8月1日 · Methodological progresses and piling evidence prove the rG4 biology in vivo. rG4s step in virtually every aspect of RNA biology. Helicases unwinding of rG4s is a fine …
Nature：揭示DDX3X通过调节NLRP3炎性体决定着应激细胞的生死 …
2019年9月18日 · DDX3X是一种酶，当发生突变时，参与多种癌症的产生，比如 乳腺癌 、肺癌和脑癌，包括成神经管细胞瘤，即一种最为常见的恶性儿童脑瘤。 DDX3X突变也与DDX3X综合 …
The mechanism of RNA duplex recognition and unwinding by …
2019年7月12日 · Here, we describe the structure of a D1D2 core in complex with a 23-base pair dsRNA at pre-unwound state, revealing that two DDXs recognize a 2-turn dsRNA, each DDX …
DEAD-Box RNA Helicases and Genome Stability - PMC
DEAD-box RNA (DDX) helicases are characterized by the presence of a specific amino acid motif, Asp-Glu-Ala-Asp (DEAD). DDX helicases comprise highly conserved core domains that …