Human DDX6 regulates translation and decay of inefficiently
2024年7月11日 · Here, we demonstrated that the human ortholog of Dhh1p, DDX6, triggers the deadenylation-dependent decay of inefficiently translated mRNAs in human cells. DDX6 …
An essential role for the RNA helicase DDX6 in NMDA receptor
2024年2月6日 · The RNA helicase DDX6 is emerging as an important accessory protein for RISC function 27,28, and associates with RISC via direct binding to CNOT1 of the CCR4-NOT …
Dual mechanisms regulate the nucleocytoplasmic localization of human DDX6
2017年2月20日 · DDX6 is a conserved DEAD-box protein (DBP) that plays central roles in cytoplasmic RNA regulation, including processing body (P-body) assembly, mRNA decapping, …
RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal
2023年2月6日 · We found that adenosine deaminases that act on RNA 1 (ADAR1) interact with DDX6 in the nucleus. Utilizing our newly developed dual-fluorescence reporter assay, we …
RNA decay in processing bodies is indispensable for adipogenesis
2021年3月17日 · In this study, we investigated Ddx6, an essential component of processing bodies (PBs) that executes RNA decay and translational repression in the cytoplasm and …
The DEAD-box RNA-binding protein DDX6 regulates parental RNA …
2018年10月1日 · The RO60/DDX6 axis regulates RNA decay for pre-existing RNAs at the early reprogramming stage. To determine whether RNA decay or translational repression occurs in …
RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal …
The RNA-binding ability and RNA helicase activity of DDX6 contribute to its function in regulation of various pathways in RNA metabolism: processing body (P-body) formation, miRNA …
DDX RNA helicases: key players in cellular homeostasis and innate ...
2024年8月30日 · DDX helicases, a conserved group of RNA-binding proteins, regulate various cellular RNA processes, including ribosome biogenesis, translation, and splicing, which require …
Human DDX6 effects miRNA-mediated gene silencing via direct ... - PubMed
Importantly, mutations that disrupt the DDX6-CNOT1 interaction impair miRISC-mediated gene silencing in human cells. Thus, CNOT1 facilitates recruitment of DDX6 to miRNA-targeted …
DDX6 and its orthologs as modulators of cellular and viral RNA ...
DDX6 (Rck/p54), a member of the DEAD-box family of helicases, is highly conserved from unicellular eukaryotes to vertebrates. Functions of DDX6 and its orthologs in dynamic …