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2021年7月21日 · 丝裂原活化蛋白激酶MAPK信号途径是细胞中大佬级别的信息传递链，由细胞内广泛表达的Ser/Thr蛋白激酶，参与细胞的生长、发育、分化、凋亡等一系列细胞生理活动，是诱发肿瘤产生的重灾区。 目前，虽然研究MAPK信号传导与肿瘤之间关系取得了不错的进展，但要完全揭示其机制，还需要更加深入的研究。 已知的 MAPK信号通路 有四类，今天我们主要介绍其中Ras/Raf/MEK/ERK途径与肿瘤千丝万缕的关系。 熟悉信号通路的童鞋们肯定知道Ras、Raf …

MAPK通路有4种主要的分支路线： ERK 、 JNK 、 p38 /MAPK和ERK5。 其中，JNK和p38功能相似，跟炎症、凋亡、生长都有关；ERK主要管细胞生长、分化，其上游信号是著名的 Ras/Raf 蛋白。 且分支路线所使用3种激酶都是不同的，可作为通路中的Biomarker。 近二十年来，世界范围内最吸金的研究方向当属细胞信号通路与肿瘤之间的恩恩怨怨。 丝裂原活化蛋白激酶MAPK信号途径是细胞中大佬级别的信息传递链，由细胞内广泛表达的Ser/Thr蛋白激酶，参与细胞的生长、 …

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2014年1月6日 · The MAPK p38α is a key regulator of bone loss and p38 inhibitors preserve bone mass by inhibiting osteoclastogenesis. p38 function is regulated by two upstream MAPK kinases, namely MKK3 and MKK6.

2024年10月18日 · In this study, we used bioinformatic approaches to identify and analyze the rice MPK kinases (MKKs) based on the complete genome. A total of seven OsMKKs were identified, and their physical and chemical properties, chromosome localization, gene structure, subcellular localization, phylogeny, family evolution, and cis-acting elements were evaluated.

2005年6月1日 · Scaffolding proteins organize MKK–MAPK complexes for activation by specific MKKKs and do so in specific locations in the cell. It is the MKKK associated with the scaffolded complex that provides selectivity for activation by upstream stimuli including GTPases, additional kinases and receptors.

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