2023年11月1日 · Calcium channel blockers (CCBs) are split into two categories, dihydropyridines (DHP), such as amlodipine and nicardipine, and non-dihydropyridines (non-DHP), such as verapamil and diltiazem. While these two drug classes are both CCBs, there are some key similarities and differences that are important to take into consideration when prescribing ...

2024年2月22日 · Calcium channel blockers (CCBs), also known as calcium channel antagonists, have been approved by the US Food and Drug Administration (FDA) and are widely used to treat various conditions such as hypertension, coronary heart disease, and chronic stable angina.

2025年3月4日 · Dihydropyridines are a type of calcium channel blocker (CCB), which refer to a group of medications that block calcium channels located in the muscle cells of the heart and arterial blood vessels, thereby reducing the entry of calcium ions into the cell.

Dihydropyridine: Think Amlodipine and Nifedipine (-dipine) They act through systemic vascular vasodilation of arteries. Can be used to treat angina. NOTE: can cause hypotension and cause reflex tachycardia (this is bad for patients with ischemic symptoms) Non-Dihydropyridine: Think Verapamil and Diltiazem. They act selectively on the myocardium.

Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, the dihydropyridine calcium channel blockers lower blood pressure mainly by relaxing the smooth muscle of the blood vessel walls.

Dihydropyridine calcium channel blockers work by blocking the entry of calcium into the cells through voltage-gated calcium channels present on the cells. Calcium present in the cells is responsible for contractions of the cells and muscles.

DHP CCBs are widely used clinically in the treatment of hypertension, angina pectoris, and cerebrovascular diseases. Introduced in the 1960s, DHP CCBs have undergone several changes to optimize their efficacy and safety.

Calcium-channel blockers (CCBs), comprise three distinct subgroups: benzothiazepines (e.g. diltiazem), dihydropyridines (e.g. amlodipine, nifedipine) and phenylalkylamines (e.g. verapamil). Despite this diversity, they are often referred to as a single, homogeneous class of pharmacological agents.

2012年11月18日 · DHP and non-DHP drugs are used to treat high blood pressure. While they utilize the same basic process of vasodilation, they have additional mechanisms which may make them appropriate for certain conditions. The positive, inotropic effects of DHP drugs make them ideal for patients with cardiovascular conditions.

Dihydropyridine (DHP) CCBs tend to be more potent vasodilators than non-dihydropyridine (non-DHP) agents, whereas the latter have more marked negative inotropic effects.