Probable ATP-dependent RNA helicase DHX36 also known as DEAH box protein 36 (DHX36) or MLE-like protein 1 (MLEL1) or G4 resolvase 1 (G4R1) or RNA helicase associated with AU-rich elements is an enzyme that in humans is encoded by the DHX36 gene.

2024年12月24日 · DHX36 (DEAH-Box Helicase 36) is a Protein Coding gene. Diseases associated with DHX36 include Retinitis Pigmentosa 33 and Fanconi Anemia, Complementation Group J. Among its related pathways are Innate Immune System and Cytosolic sensors of pathogen-associated DNA.

2019年6月3日 · We identify DHX36 as a predominantly cytoplasmic RNA helicase that specifically interacts with G-rich sites of mRNAs previously shown to form rG4s in vitro 10.

2024年11月15日 · The DEAH-box helicase 36 (DHX36) is known to bind and unwind RNA G-quadruplex (rG4) structure but the transcriptome-wide RNA structure remodeling induced by DHX36 binding and the...

2024年10月4日 · Dhx36 deficiency directly influences cardiomyocyte gene networks by disrupting the resolution of promoter G-quadruplexes in key cardiac genes, impacting cardiomyocyte differentiation and CCS...

2024年5月1日 · DEAH-box helicase 36 (DHX36) is a significant G4 helicase that plays a vital role in various biological processes by unwinding DNA G4s and RNA G4s. Up to now, numerous researches have investigated the role of DHX36 in cancer, aging, neurodegeneration, and viral infections [[13], [14], [15]].

dhx36（也称为 rhau 和 g4r1）是 deah/rha 解旋酶家族的成员，以极高的亲和力结合 dna 和 rna g 四链体 4-6，始终被发现与细胞中的 g 四链体结合 7,8 和是 hela 细胞裂解物中 g-四链体解折叠活性的主要来源6。

2025年2月9日 · The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes. The DHX36-specific-motif (DSM) enhances specificity by accelerating recruitment of DNA G-quadruplex structures. DHX36, BAX, and ARPC1B May Be Critical for the Diagnosis and Treatment of Tuberculosis.

我院范衡宇课题组于Science Bulletin杂志在线发表题为DHX36-mediated G-quadruplexes unwinding is essential for oocyte and early embryo development in mice的研究长文。该研究首次发现哺乳动物卵母细胞和早期胚胎发育过程中G-四链体（G-quadruplex, G4）结构的形成与DHX36的分布具有时空一致性，揭示了DHX36参与结合与解开DNA及pre ...

2020年12月1日 · The DEAH-box polypeptide 36 (DHX36) has been identified as a dominant nucleic acid helicase which targets and disrupts DNA and RNA G4s in an ATP-dependent manner. However, the actual role of DHX36 in breast cancer remains unknown.