We show that Dkk3 is upregulated in both hip and knee OA and in both synovial tissue and cartilage from diseased joints. Dkk3 upregulation is also reported in OA subchondral bone from patients undergoing TKR 29. This suggests Dkk3 is relevant to whole joint biology in two common sites of disease.

We provide evidence that Dkk3 is upregulated in OA and may have a protective effect on cartilage integrity by preventing proteoglycan loss and helping to restore OA-relevant signaling pathway activity. Targeting Dkk3 may be a novel approach in the treatment of OA.

2020年12月16日 · Dickkopf-related protein 3 (DKK3) is a secreted glycoprotein that has been implicated in the pathogenesis of a variety of diseases. Recent evidence suggests that urinary DKK3 may serve as a potential biomarker for monitoring kidney disease progression and assessing the effects of interventions.

2024年12月24日 · DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3) is a Protein Coding gene. Diseases associated with DKK3 include Isolated Polycystic Liver Disease and Polycystic Liver Disease. Among its related pathways are Regulation of Wnt / B-catenin signaling by small molecule compounds and Hair follicle development: cytodifferentiation - part 3 of 3.

2020年6月12日 · Dkk3 is a member of the Dickkopf family proteins, which are well-known Wnt signaling pathway inhibitors. We first tested the ability of Dkk3 to inhibit the canonical Wnt pathway, by analyzing 2 important signal transducers …

2018年5月1日 · Here we identified Dkk3 as the key secreted factor generated by muscles to induce sarcopenia and characterized the mechanism of Dkk3-dependent transcription activation of Fbxo32 and Trim63.

Dkk3 expression is increased in OA but can be regulated IL1 and OSM. This suggests a balance of Dkk3 effects depending upon the biological stimuli within the cartilage. Dkk3 may act in a protective role in the presence of inflammatory cytokines as …

Dickkopf‑related protein 3 (DKK3) is an atypical member of the Wnt‑antagonistic dickkopf‑related protein (DKK) family. The availability of research into the role of DKK3 in the abnormal remodeling of subchondral bone in human knee joints is currently limited.

2019年2月28日 · To determine the role of a cytokine-like protein DKK3 (dikkopf-3) in directly transdifferentiating fibroblasts into endothelial cells (ECs) and the underlying mechanisms. DKK3 overexpression in human fibroblasts under defined conditions for 4 days led to a notable change in cell morphology and progenitor gene expression.

2025年2月13日 · This review delves into the role of Dickkopf-3 (DKK3), a secreted glycoprotein and member of the Dickkopf family, in non-malignant diseases. DKK3 is particularly known for its regulatory effects on the Wnt signaling pathway, a critical mediator in various biological processes including cell prolifer …