Downregulation of dihydrolipoyl dehydrogenase by UVA …
More so, suppression of DLD significantly inhibits in vivo melanoma growth and tumor proliferation. In addition, suppression of DLD increased the NAD+/NADH ratio in melanoma …
细胞代谢 | 三羧酸循环与铜死亡 - 知乎 - 知乎专栏
2022年3月在Science期刊发表的Copper induces cell death by targeting lipoylated TCA cycle proteins揭示了铜离子过载会导致细胞死亡，细胞铜稳态失衡，铜离子直接结合三羧酸循环酯 …
Science 铜死亡 | 铜离子通过靶向三羧酸循环途径中的脂酰化蛋白诱 …
所以作者就猜，fdx1 会不会可能是蛋白脂酰化的上游调节因子，进而调节tca循环呢？ 为了验证这个假设，接下来他们进行了三个分析。 首先，作者在Cancer Dependency Map ( http://www. …
铜诱导的细胞死亡相关蛋白 DLD 在人类癌症中的致癌作用：泛癌 …
二氢硫辛酰胺脱氢酶 (dld) 是 tca 循环的关键蛋白，构成 α-酮戊二酸脱氢酶复合物的 e3 组分，与 tca 循环中的线粒体电子传递链深度互连。 肿瘤细胞表现出对谷氨酰胺分解燃料的依赖，以进行 …
Oncogenic role of copper‑induced cell death‑associated protein DLD …
2023年4月6日 · Copper ions can bind directly to lipoylated components of the tricarboxylic acid (TCA) cycle, triggering the aggregation of mitochondrial lipoylated proteins and the …
Dihydrolipoamide dehydrogenase regulates cystine deprivation …
Dihydrolipoamide dehydrogenase (DLD) gene silencing blocked cystine deprivation- or sulfasalazine-induced ferroptosis in vitro and in vivo, which was restored by resistant DLD …
Roles of Dihydrolipoamide Dehydrogenase in Health and Disease
In this article, the authors review the different roles of DLDH in selected pathological conditions, including its deficiency in humans, its role in stroke and neuroprotection, skin photoaging, …
Pan-Cancer Analysis of the Cuproptosis-Related Gene DLD
2023年11月30日 · DLD expression levels were significantly correlated with survival, immune cell infiltration, tumor mutational status, and microsatellite instability (MSI). DLD can be used as a …
UVA下调二氢脂酰脱氢酶可通过触发氧化应激和改变能量代谢来抑 …
二氢脂酰脱氢酶（dld）是一种具有心肌黄递酶活性的线粒体酶。 在这里，我们报告DLD在黑色素瘤细胞进展和增殖中的关键作用。 低强度UVA（125 mJ / cm 2）抑制DLD表达增加了细胞 …
科学网—【第八十期】铜离子靶向TCA循环中的乙脂酰化蛋白诱导 …
2022年3月18日，麻省理工学院和哈佛大学等人在Science杂志发表了题为“Copper induces cell death by targeting lipoylated TCA cycle proteins”的研究论文，该研究发现了一种新的细胞死亡 …