More so, suppression of DLD significantly inhibits in vivo melanoma growth and tumor proliferation. In addition, suppression of DLD increased the NAD+/NADH ratio in melanoma cells and also inhibits TCA cycle related metabolites.

2022年3月在Science期刊发表的Copper induces cell death by targeting lipoylated TCA cycle proteins揭示了铜离子过载会导致细胞死亡，细胞铜稳态失衡，铜离子直接结合三羧酸循环酯酰化蛋白， FDX1 /LIAS介导的LA pathway（ 硫辛酸 途径）诱导硫辛酸化修饰的DLAT（ 丙酮酸脱氢酶 …

所以作者就猜，fdx1 会不会可能是蛋白脂酰化的上游调节因子，进而调节tca循环呢？ 为了验证这个假设，接下来他们进行了三个分析。 首先，作者在Cancer Dependency Map ( http://www. depmap.org ) 中找FDX1和硫辛酸协调依赖的证据，这个网站拥有数百个癌症细胞系中进行全 ...

二氢硫辛酰胺脱氢酶 (dld) 是 tca 循环的关键蛋白，构成 α-酮戊二酸脱氢酶复合物的 e3 组分，与 tca 循环中的线粒体电子传递链深度互连。 肿瘤细胞表现出对谷氨酰胺分解燃料的依赖，以进行 TCA 循环和支持肿瘤生长的基本生物合成过程。

2023年4月6日 · Copper ions can bind directly to lipoylated components of the tricarboxylic acid (TCA) cycle, triggering the aggregation of mitochondrial lipoylated proteins and the destabilization of Fe-S cluster proteins, resulting in copper-dependent cell death. Dihydrolipoamide dehydrogenase (DLD) is a key prot …

Dihydrolipoamide dehydrogenase (DLD) gene silencing blocked cystine deprivation- or sulfasalazine-induced ferroptosis in vitro and in vivo, which was restored by resistant DLD cDNA; this suggested a close relationship between DLD and cystine deprivation-induced ferroptosis.

In this article, the authors review the different roles of DLDH in selected pathological conditions, including its deficiency in humans, its role in stroke and neuroprotection, skin photoaging, Alzheimer's disease, and DLDH as a nondehydrogenating protein, and construction of genetically modified DLDH animal models for further studying the role ...

2023年11月30日 · DLD expression levels were significantly correlated with survival, immune cell infiltration, tumor mutational status, and microsatellite instability (MSI). DLD can be used as a new prognostic marker for various malignancies and as an indicator of …

二氢脂酰脱氢酶（dld）是一种具有心肌黄递酶活性的线粒体酶。 在这里，我们报告DLD在黑色素瘤细胞进展和增殖中的关键作用。 低强度UVA（125 mJ / cm 2）抑制DLD表达增加了细胞内ROS的产生，并降低了线粒体膜电位，从而诱导自噬细胞死亡，这可通过黑色素瘤细胞 ...

2022年3月18日，麻省理工学院和哈佛大学等人在Science杂志发表了题为“Copper induces cell death by targeting lipoylated TCA cycle proteins”的研究论文，该研究发现了一种新的细胞死亡方式-铜死亡。