PI3K/Akt/YAP signaling promotes migration and invasion of DLD-1 ...
2022年2月3日 · To determine whether the PI3K/Akt and/or MEK/ERK pathways regulate YAP activation and therefore promote the migration and invasion of DLD-1 cells, we examined the …
Differential contribution of the ERK and JNK mitogen-activated
1999年3月15日 · We found that upregulation of Raf/MEK/ERK and JNK correlated with expression of oncogenic Ras in HT1080, but not DLD-1 cells. Furthermore, inhibition of ERK …
RPL36A activates ERK pathway and promotes colorectal cancer …
2025年1月1日 · Extracellular Signal-Regulated Kinase (ERK) constitutes a crucial component of the Epidermal Growth Factor Receptor (EGFR)/Ras/MEK/ERK pathway, which is frequently …
SHOC2 complex-driven RAF dimerization selectively contributes to ERK …
2019年7月7日 · Our study has uncovered a selective contribution of the SHOC2 phosphatase complex to ERK pathway dynamics. In DLD-1 cells EGF stimulates ERK pathway activation in …
Snail1 expression in human colon cancer DLD-1 cells confers …
2016年12月1日 · DLD-1 cells, a cell line derived from human colorectal cancer, display epithelial properties such as a cobblestone cell shape. We introduced a control vector encoding DsRed …
Dihydrolipoyl dehydrogenase promotes white adipocytes …
2024年4月1日 · Cellularly, DLD was found to promote white adipocytes browning by activating mitochondrial function through the RAS/ERK pathway. Further studies revealed that the …
Induction of S-phase arrest and p21 overexpression by a small
2004年5月3日 · Our study showed that 2,3-DCPE could induce p21 expression and S-phase arrest in cancer cells correlated with ERK activation that is p53- and ATM-dispensable. We …
Differential contribution of the ERK and JNK mitogen-activated …
1999年3月11日 · We found that upregulation of Raf/MEK/ERK and JNK correlated with expression of oncogenic Ras in HT1080, but not DLD-1 cells. Furthermore, inhibition of ERK …
ORP8对结直肠癌DLD-1细胞增殖、迁移和侵袭能力的影响_参考网
2021年7月2日 · 已有多项研究表明，在结直肠癌中，通过影响ERK信号传导可以调控EMT，另外也有研究表明，ERK信号通路激活与否影响着细胞的迁移能力，而且在Kattan et al的报道中，提 …
Targeting the PI3K signaling pathway in KRAS mutant colon …
Human CRC cell lines with KRAS mutations (DLD-1, HCT116, and LoVo) were used to test the effect of cetuximab, BKM120, and cetuximab plus BKM120 on cell proliferation in vitro and in …
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