Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin.

Key words: Diabetes mellitus, endocrinopathies, gestational diabetes, maturity-onset diabetes of the young, neonatal diabetes. INTRODUCTION. Diabetes mellitus (DM), also known simply as diabetes is a complex metabolic disorder characterized by hyperglycemia, a physiologically abnormal condition represented by continued elevated blood glucose ...

2020年1月3日 · Type 1 and 2 DM are the main subtypes, each with different pathophysiology, presentation, and management, but both have a potential for hyperglycemia. This activity outlines the pathophysiology, evaluation, and management of DM and highlights the role of the interprofessional team in managing patients with this condition.

2023年9月1日 · The pathophysiology of type 2 diabetes mellitus is distinguished by insulin deficiency and insulin resistance, which have been linked to inflammatory cytokines in the plasma and high levels of fatty acids, leading to deficient glucose transport into target cells, elevated breakdown of fat, and increased hepatic glucose production [29 ...

2024年10月2日 · Type 2 diabetes (T2D) is a disease characterized by heterogeneously progressive loss of islet β cell insulin secretion usually occurring after the presence of insulin resistance (IR) and it...

2020年10月13日 · Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which results from abnormalities in either insulin secretion or insulin action or both. Hyperglycemia manifests in various forms with a va …

2025年3月1日 · Diabetes mellitus (DM) is a progressive metabolic disease characterised by high blood glucose due to autoimmune destruction of the β-islet of Langerhans or gradual development of insulin resistance and β-cell degeneration. Numerous risk factors, from genetic to environmental, are associated with this disease.

2022年2月1日 · This review focus on the mechanisms by which oxidative stress, mitochondrial dysfunction, ER stress, and inflammation are involved in the pathophysiology of T2D, highlighting the importance of the antioxidant response and DNA repair mechanisms counteracting the development of the disease.

2021年8月3日 · This article explores the pathophysiology, clinical manifestations, diagnostic tests, and treatments for type 2 diabetes mellitus based on the current best-available evidence. Read more Article

By better understanding the pathophysiology and natural history of various subtypes of diabetes and applying what we know about the modes of action and pharmacogenomics of existing therapies, we can better apply a personalized approach to diabetes management.