2019年3月3日 · Following a successful launch early Saturday morning, SpaceX’s Crew Dragon spacecraft has successfully conducted a rendezvous and docking to the International Space Station for the first time....

2021年1月1日 · Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity and lack of crystallographic data makes noncoding RNA regions challenging targets to study in the field of drug discovery.

2025年3月15日 · We developed a novel DNA aptamer, D8#24S1, which specifically recognizes mertansine (DM1), the cytotoxic payload of the antibody-drug conjugate (ADC) trastuzumab emtansine (T-DM1), and applied it for T-DM1 analysis.

2023年1月3日 · Flow charts for dynamic docking (DyanD) (a) and dynamic docking/AutoDock (DynaD/Auto) (b) approaches to predict binding free energies of small molecules targeting RNA C U G repeats. See Video S1 displaying the initial docking stage of DynaD.

2019年3月3日 · Main Docking Article: https://www.nasaspaceflight.com/2019/03/crew-dragon-first-docking-iss-dm1/ - By Thomas Burghardt Main Update Thread for the launch:...

Crew Dragon Demo-1 (officially Crew Demo-1, SpaceX Demo-1, or Demonstration Mission-1) [a] was the first orbital test of the Dragon 2 spacecraft. The mission launched on 2 March 2019 [3][4] at 07:49:03 UTC, and arrived at the International Space Station on 3 March 2019, a little over 24 hours after the launch.

Expansion of RNA CUG repeats causes myotonic dystrophy type 1 (DM1). Once transcribed, the expanded CUG repeats strongly attract muscleblind-like 1 (MBNL1) proteins and disturb their functions in cells.

What do "Undocking" and "Departed" mean? The docking times also differ between the two quotes, the first one is 10:51, the second one is 8:51 (2 hours earlier, just as "departed" is 2 hours earlier than "undocking").

... changes in the gas chromatograms in the time before SpX-DM1 and during docked operations are striking. As seen in Figure 2 A, prior to SpX-DM1, IPA appeared in the chromatogram as a very...

2007年3月16日 · To further test if the arginine residues in DM1 are critical for docking interactions, we have mutated two arginine residues to alanine (Npl3pDM1 R-A) and tested its binding interaction with His-Sky1p by GST co-precipitation experiment.