Methylhexanamine (also known as methylhexamine, 1,3-dimethylamylamine, 1,3-DMAA, dimethylamylamine, and DMAA; trade names Forthane and Geranamine) is an indirect sympathomimetic drug invented and developed by Eli Lilly and Company and marketed as an inhaled nasal decongestant from 1948 until it was voluntarily withdrawn from the market in the ...

Dimethylamylamine (DMAA) was a forgotten pharmaceutical that was patented in 1944 as a nasal decongestant. DMAA has recently gained popularity as a dietary supplement,...

Dimethylamylamine (DMAA) is a component of many dietary supplements and has recently been associated with numerous adverse effects, prompting the US military and World Anti-Doping Agency to ban its use as a supplement. The current study aimed to elucidate the abuse liability profile of DMAA.

2019年10月21日 · I've never tried stimulants other than caffeine before but I took DMAA in a pre workout supplement and felt fucking incredible, and from my reading it looks like the chemical structure of DMAA is very similar to amphetamine/meth so I was wondering if anyone personally knows how similar any of them are

LC-MS-MS analysis revealed the presence of DMAA in 92.3% of the false-positive samples at a concentration of approximately 6.0 mg/L DMAA, causing a positive screen on both immunoassay kits. The Department of Defense (DoD) operates six forensic urine drug-testing laboratories that screen close to 5 million urine samples for amphetamines yearly.

2012年7月20日 · The Therapeutic Goods Administration (TGA) has considered a proposal to list 1,3-dimethylamylamine (DMAA) as a schedule 9 compound. Schedule 9 compounds are prohibited substances which have no ...

Data in the publicly available scientific literature raises concerns about the safety of DMAA. The structure of DMAA is similar to methamphetamine (Gee et al., 2012), which alone is cause for...

2022年10月12日 · DMAA is a stimulant and vasoconstrictor, that is, it narrows blood vessels and arteries and increases blood pressure. FDA warns this could lead to problems such as heart attack, shortness of breath, and tightening of the chest.

2012年1月25日 · DMAA has recently gained popularity as a dietary supplement, with claims of effectiveness as an athletic performance enhancer and weight loss aid. It is also sold as a recreational stimulant drug. DMAA is a sympathomimetic and potent pressor agent. This report describes 3 cases of cerebral hemorrhage in adults after the use of DMAA.

2015年1月1日 · Dimethylamylamine (DMAA) is a component of many dietary supplements and has recently been associated with numerous adverse effects, prompting the US military and World Anti-Doping Agency to ban its use as a supplement. The current study aimed to elucidate the abuse liability profile of DMAA.

2018年7月18日 · Peer-reviewed published clinical trials, as a whole, show that acute (single serving) or subchronic (approximately 12 weeks) DMAA ingestion at doses at or below levels recommended on Hi-Tech product labels (=90 mg per serving) are safe for healthy individuals, and do not indicate clinically-relevant adverse health effects.

DMAA appears to provide a sympathomimetic effect in human subjects. It mimics the effects on the sympathetic nervous system of neurotransmitters such as epinephrine, norepinephrine and dopamine. By doing so, it delivers a stimulatory effect, as well as a claimed feeling of euphoria a response cited in several anecdotal reports.

2013年6月7日 · In a recent Google search, many websites devoted to bodybuilding and health supplementation have made the claim that DMAA is safe or at least is safe in “appropriate” doses while recognizing that taking too much can have adverse effects. …

1,3-DMAA is an indirect agonist of noradrenaline (NA) due to its capability to inhibit NAT, the reuptake transporter of this neurotransmitter [49,50,51]. 1,3-DMAA was also shown to have no effect over the dopamine transporter (DAT), serotonin transporter (SERT) [49,50] and trace amine-associated receptor 1 (TARR1) .

2021年11月3日 · DMAA is a synthetic drug found in dietary supplements and promoted to enhance weight loss and athletic performance. For many years, it was used as a nasal decongestant but was removed from the market because of several safety concerns. What are the health effects and dangers of DMAA? Read on to find out.

2015年1月1日 · In the present study, DMAA produced locomotor depression, fully substituted for the discriminative stimulus effects of cocaine, produced partial substitution for methamphetamine (77% drug-appropriate responding), and produced a conditioned place preference.

Dimethylamylamine (DMAA) was a forgotten pharmaceutical that was patented in 1944 as a nasal decongestant. DMAA has recently gained popularity as a dietary supplement, with claims of effectiveness as an athletic performance enhancer and weight loss aid. It is also sold as a recreational stimulant drug.

The alkylamine stimulant 1,3-dimethylamylamine (DMAA) is used nonmedically as an appetite suppressant and exercise performance enhancer despite adverse cardiovascular effects that have limited its legal status. There is scant research describing the mechanism of action of DMAA, making it difficult to gauge risks or therapeutic potential.

2015年1月1日 · The cocaine- and methamphetamine-like discriminative stimulus effects and the conditioned place preference produced by DMAA suggest that is has potential for abuse. These findings in combination with reports of substantial adverse effects of DMAA in humans suggest that control of DMAA may warrant fu …

The psychostimulants d-amphetamine (AMPH) and methamphetamine (METH) release excess dopamine (DA) into the synaptic clefts of dopaminergic neurons. Abnormal DA release is thought to occur by reverse transport through the DA transporter (DAT), and it ...