A parabrachial-hypothalamic parallel circuit governs cold defense …
2023年8月15日 · To test whether there is a direct connection between LPB SST and DMH neurons, we expressed ChR2 in LPB SST neurons (Fig. 6h, i) and found that light stimuli induced EPSCs from DMH neurons...
Cholinergic neurons in the dorsomedial hypothalamus regulate mouse ...
2015年6月1日 · To study the physiological function of DMH cholinergic neurons, we generated transgenic mice expressing channelrhodopsin fused to yellow fluorescent protein (YFP) selectively in cholinergic neurons (ChAT-Cre::ChR2-YFP). The DMH from these transgenic animals also showed the expression of cholinergic neurons as identified by YFP fluorescence ...
Paraventricular hypothalamic RUVBL2 neurons suppress appetite …
2024年10月16日 · PVH RUVBL2 → DMH is another neural circuit mediating the anorexigenic effect of PVH RUVBL2 neurons. The DMH controls energy homeostasis through regulating food intake and energy expenditure...
【前沿进展】Science | 大脑控制心率的秘密——从ACC到心脏的多 …
2024年8月15日 · acc→vmt→dmh→amb通路构成了操控性低心率的自上而下调控通路 图5a-5d显示，通过在背内侧丘脑(vmt)注射病毒载体表达光敏蛋白chr2，可以在急性脑片 ...
Cell-type-specific hypothalamic pathways to brainstem drive …
2024年6月3日 · In order to activate the excitatory neurons in the DMH, we expressed Channelrhodopsin-2 (ChR2) bilaterally in the DMH of vesicular glutamate transporter 2 (VGluT2) -Cre mice through injection of an adeno-associated virus (AAV) (Figure 2D).
Heat acclimation in mice requires preoptic BDNF neurons and ...
2024年12月26日 · These neurons orchestrate downstream targets in the dorsomedial hypothalamus (DMH) and rostral raphe pallidus (rRPa) to mediate HA effects. BDNF, acting through its receptor tropomyosin-related...
Cholinergic neurons in the dorsomedial hypothalamus regulate …
2015年4月11日 · The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory signals and regulates adaptive thermogenesis. Here, we study the function and synaptic connectivity of input from DMH cholinergic neurons to sympathetic premotor neurons in …
下丘脑背内侧核中不同类型神经元对焦虑的影响 - 学术堂
2019年6月12日 · DMH与中央外侧杏仁核、中央内侧杏仁核、导管周围灰质、终纹床核 (Bed Nucleus of Stria Terminalis) 以及迷走神经背复合体 (Dorsal Vagal Complex) 等多种焦虑相关脑区存在投射关系, 并对其具有靶向调节作用[22]。越来越多研究证实, DMH在调节着体温、摄食、饮水 …
A Hypothalamic Switch for REM and Non-REM Sleep
2018年3月7日 · To express channelrhodopsin 2 (ChR2) in the POA-projecting neurons, we injected Cre-inducible rAAV2-retro-ChR2-eYFP into the POA of GAL-Cre mice and implanted an optic fiber into the DMH (Figures 4 A and S4 A).
Dorsomedial and preoptic hypothalamic circuits control torpor
Next, we examined whether activation of DMH GABAergic neurons is sufficient to induce torpor. To this end, we injected Vgat-cre mice unilaterally with AAV expressing Cre-dependent channelrhodopsin 2 (ChR2), or eYFP as control, in the DMH (Figure S4A).