DNA replication occurs in all living organisms acting as the most essential part of biological inheritance. This is essential for cell division during growth and repair of damaged tissues, while it also ensures that each of the new cells receives its own copy of the DNA. [5] .

DNA re-replication (or simply rereplication) is an undesirable and possibly fatal occurrence in eukaryotic cells in which the genome is replicated more than once per cell cycle. [1] Rereplication is believed to lead to genomic instability and has been implicated in the pathologies of a variety of human cancers . [ 2 ]

在分子生物学中，DNA复制（DNA replication）是指DNA双链在细胞分裂 间期阶段进行以一个初始DNA分子产生两个相同的DNA复制品的生物过程 [1] 。 DNA 复制发生在所有 真核 生物体 中，是生物 遗传 中最重要的机制；除了对于生长和受损组织修复过程中的细胞分裂至关 ...

3 天之前 · DNA replication is the process by which the genome’s DNA is copied in cells. Before a cell divides, it must first copy (or replicate) its entire genome so that each resulting daughter cell ends up with its own complete genome. DNA replication is probably one of the most amazing tricks that DNA does.

We developed an extension of a mathematical model of normal DNA replication to allow origin re-firing, resulting in a stochastic hybrid model of DNA re-replication. Contrary to normal DNA replication, where exactly two DNA copies are produced, in re-replication origin re-firing allows each origin to produce multiple copies (referred to here as ...

2024年11月27日 · Biochemical and structural studies of the human MCM replicative DNA helicase complex show differences from the yeast complex and provide insights into mechanisms of double hexamer assembly on...

DNA replication is an intricate and ingenious procedure that is fundamental to cellular life. Incomplete or erroneous DNA replication events lead to aberrated cell cycles, gene mutations, and gene copy number variations, further resulting in diseases, even cancer. 1 , 2.

Loss of proper licensing control leads to deregulated DNA replication including DNA re-replication, which can cause genome instability and tumorigenesis. Eukaryotic organisms have established several conserved mechanisms to prevent DNA re-replication and …

6 天之前 · "The DNA double helix is one of the most recognizable molecular structures in science," Dr. Batra says. ... and now our study provides a much clearer understanding of how they work and why they're ...

2025年3月7日 · Their findings, which were published March 7 in Science, one of world’s leading scientific journals, not only reveal new details about how secondary DNA structures like G4s can impede DNA replication, but also offer new insights into fundamental human biology.. The study was led by co-first authors Sahil Batra, PhD, a research scholar in the lab of senior author Dirk Remus, PhD, and Benjamin ...