Tat stands for "Trans-Activator of Transcription". The protein consists of between 86 and 101 amino acids depending on the subtype. [3] Tat vastly increases the level of transcription of the …

摘要: 穿膜肽TAT 被证实可用于不同类型药物分子的递送, 包括核酸、蛋白质和小分子药物等。TAT可以通过共价连接和非共价连接等形式递送分子。但是迄今TAT采用非共价连接形式递送 …

1型 人免疫缺陷病毒转录激活因子TAT （human immunodeficiency virus-1 transcription activator， HIV-1 TAT）是第一个被发现的细胞穿透肽，它凭借一种无毒的、高效的方式进入细胞。 细胞 …

2021年11月1日 · HIV-1 Tat uses different strategies to induce gene transcription. Tat binds with TAR hairpin to promote HIV-1 replication via p-TEFb recruitment. Tat also uses an alternative …

Tat is a small, versatile, viral protein that controls transcription of the HIV genome, regulates cellular gene expression and generates a permissive environment for viral replication by …

2024年12月3日 · Tat stimulates several-fold the replication in vivo of DNA initiated at the JCV origin; HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas …

2014年4月25日 · Complexes of the TAT peptide with plasmid DNA (pDNA) show unusually high transfection efficiency when condensed via “soft” calcium cross links. In this study, we …

2009年8月11日 · In an attempt to understand how the viral transcriptional factor Tat is initially synthesized for the sustained expression of the viral DNA in newly HIV-1 infected cells, we …

2006年7月1日 · The results of microarray assays demonstrated that the DNA repair gene PRKDC (encoding DNA-PKcs) was downregulated in the HIV-1 Tat-expressing cells. DNA-PKcs, the …

2024年8月30日 · Mechanistically, we uncovered that methylation of the TAT promoter was significantly increased by DNA methyltransferase 3 (DNMT3A/3B). In addition, reduced TAT …