Tat stands for "Trans-Activator of Transcription". The protein consists of between 86 and 101 amino acids depending on the subtype. [3] Tat vastly increases the level of transcription of the …

摘要: 穿膜肽TAT 被证实可用于不同类型药物分子的递送, 包括核酸、蛋白质和小分子药物等。TAT可以通过共价连接和非共价连接等形式递送分子。但是迄今TAT采用非共价连接形式递送 …

Nov 1, 2021 · HIV-1 Tat uses different strategies to induce gene transcription. Tat binds with TAR hairpin to promote HIV-1 replication via p-TEFb recruitment. Tat also uses an alternative P …

1型 人免疫缺陷病毒转录激活因子TAT （human immunodeficiency virus-1 transcription activator， HIV-1 TAT）是第一个被发现的细胞穿透肽，它凭借一种无毒的、高效的方式进入细胞。 细胞 …

Tat is a small, versatile, viral protein that controls transcription of the HIV genome, regulates cellular gene expression and generates a permissive environment for viral replication by …

Human immunodeficiency virus type 1 (HIV-1) encodes a transactivator of transcription (Tat) protein, which has several functions that promote viral replication, pathogenesis, and disease.

Thyroid hormone (T3) receptor alpha (T3Ralpha) binds to HIV-1 Tat, an interaction mediated through the DNA-binding domain of T3Ralpha (amino acids 51–118) and the arginine-rich …

Feb 4, 2025 · 这项研究分析了Tat对Jurkat细胞中DNA甲基化和转录特征的影响。 用全长Tat（Tat101），Tat的第一个外显子（Tat72）或空载体转染细胞。 使用Infinium …

1 day ago · The TAT peptide, derived from the HIV-1 trans-activator of transcription protein, has a distinct amino acid sequence that enables efficient cellular uptake. The most studied variant, …

Jul 30, 2012 · Genetic variation within tat of different HIV-1 subtypes has been shown to affect the interaction of the viral transactivator with cellular and/or viral proteins, influencing the overall …