Muscle regeneration controlled by a designated DNA dioxygenase
2021年5月25日 · Tet2 activates transcription of the key differentiation modulator Myogenin (MyoG) by actively demethylating its enhancer region. Re-expressing of MyoG in Tet2 KO …
Turning on Myogenin in Muscle: A Paradigm for Understanding …
2012年6月28日 · The skeletal muscle-specific gene myogenin (Myog) is a key developmental regulator for skeletal muscle formation and is one of the better studied tissue-specific genes. …
Myogenin is required for assembly of the transcription machinery …
2021年1月19日 · We show here that MYOG is required for the recruitment of TBP and RNAPII to muscle gene promoters, indicating that MYOG is essential in assembling the transcription …
Myogenin promotes myocyte fusion to balance fibre number and size - Nature
2018年10月12日 · Adult myog mutants display reduced muscle mass, decreased fibre size and nucleation. Adult-derived myog mutant myocytes show persistent defective fusion ex vivo. …
MyoG基因结构与功能研究进展 - 百度学术
肌细胞生成素(myogenin,MyoG)是生肌调节因子MRFs(MyoD,MyoG,Myf5和MRF4)家族的一员,它的表达具有控制成肌细胞融合的起始,促使成肌细胞的增殖作用,使单核成肌细胞转变成为多核的 …
Natural antisense transcript of MYOG regulates development and ...
2023年6月25日 · Molecular biology experiments demonstrated that MYOG-NAT enhances the stability of MYOG mRNA by competing with miR-128-2-5p, miR-19a-5p, and miR-19b-5p for …
生肌调节因子及肌生成调控因素研究进展 - 百度学术
生肌调节因子（myogenic regulatory factors,MRFs）是调控肌肉生成的重要基因,家族中包括MyoD、MyoG、Myf5和Myf6。 MyoD能把多种类型细胞转化为成肌细胞,在肌肉特异基因转录 …
(PDF) Turning on Myogenin in Muscle: A Paradigm for
2012年6月28日 · Expression of the myogenin (Myog) gene is restricted to skeletal muscle cells where the transcriptional activator turns on a gene expression program that permits the …
Myogenin regulates denervation-dependent muscle atrophy in
Muscle denervation stimulates muscle atrophy and Myogenin (Myog) is a muscle-specific transcription factor that is highly induced following muscle denervation. To investigate if Myog …
NANOG restores the impaired myogenic differentiation potential …
2018年1月1日 · Here we present data showing that late passage C2C12 myoblasts exhibited significantly impaired myogenic differentiation potential that was accompanied by impaired …