2012年2月1日 · These results demonstrate the ability to create a continuous flow of a hyperpolarized liquid sample by Overhauser DNP directly in the bore of a 1.5 T imaging magnet and to use it for MRI. Compared to other liquid state (“Overhauser”) DNP approaches, where the polarization is performed outside of the bore of the imaging magnet at X-band, the ...

2017年11月1日 · DNP（动态核极化）-MRI，一种新的自由基成像方法（Lurie，et al. 1988），利用 Overhauser 效应，通过诱导电子自旋，接近自由基的核自旋比自然状态的极化高 300 倍自由基的共振。

DNP enhances the MRI signal by irradiating the target tissue or solution with the free radical molecule's electron paramagnetic resonance frequency before executing pulse sequence of the MRI. In vivo DNP-MRI with redox-sensitive nitroxyl radicals as the DNP redox contrast agent enables the imaging of the redox metabolism on various diseases.

2017年3月14日 · Here we describe a new hyperpolarization approach for magnetic resonance imaging applications at 1.5 T. Proton signal enhancements of more than 20 were achieved with a newly designed multimode...

2024年3月7日 · Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissoln. DNP can be used to perform in vivo real-time 13 C MRI.

2024年12月30日 · 动态核极化 MRI（Dynamic Nuclear Polarization MRI, DNP-MRI）是一种新兴的非侵入性成像技术，能够通过监测氧化还原探针的分布来评估组织的氧化还原状态。 本研究旨在利用 DNP-MRI 技术评估 DMD 模型小鼠（mdx 小鼠）骨骼肌的氧化还原状态，并探讨其在局部炎 …

This review aims to offer insights into the design principles of responsive DNP agents, target selection, and the mechanisms of action for imaging. Such discussions aim to propel the future development and application of DNP-based biomedical imaging agents. Keywords: MRI, dynamic nuclear hyperpolarization, biomarker, responsive agent INTRODUCTION

We have used liquid state ("Overhauser") Dynamic Nuclear Polarization (DNP) to significantly enhance the signal to noise ratio (SNR) of Magnetic Resonance Imaging (MRI). For the first time this was achieved by hyperpolarizing directly in the MRI-scanner field of 1.5 T in continuous flow mode and imm …

摘要：动态核极化是一种用于提高核磁共振灵敏度的极化转移增强技术，通过饱和自由基中的未配对电子，将电子的极化转移到核上，从而获得高极化的核自旋。 由于突出的极化增强效果，动态核极化技术已成为当今国际上的研究热点，但是，目前国内对动态核极化相关硬件技术的研究还比较少，特别是对极化转移效率起着决定性作用的探头更是鲜有报道，本文以此为背景对其关键技术进行了深入的研究。 本文首先简单介绍了动态核极化原理及其系统结构，接着对动态核极化探 …

2024年10月1日 · DNP-MRI enables visual verification of IMRT in vivo. Quantitative visualization of irradiated dose from signal values is expected with the accumulation of data. Therefore, this study has potential for application to new systems such as MR-Linac for more precise radiotherapy.