多萜醇是以胆固醇合成的中间体IPP和FPP为原料合成的，被多萜醇激酶（DOLK）用CTP磷酸化，生成 磷酸多萜醇 （Dol-P）。 在内质网膜的胞质面上，磷酸多萜醇与UDP-GlcNAc反应，生成GlcNAc-PP-Dol结构。

2017年7月25日 · The generation of glycolipid dolichylphosphate mannose (Dol-P-Man) is a critical step for protein glycosylation and GPI anchor synthesis.

Dolichol-phosphate mannose (Dol-P-Man) 作为内质网 (ER) 腔侧甘露糖基残基的供体。 缺乏 Dol-P-Man 会导致 GPI 锚定蛋白的表面表达缺陷。 Dol-P-Man 由 GDP-甘露糖和多萜醇磷酸在 ER 的胞质侧通过多萜醇磷酸甘露糖基转移酶合成。 由该基因编码的蛋白质是多萜醇磷酸甘露糖基转移酶的一个亚基，并充当多萜醇磷酸甘露糖基转移酶复合物的稳定剂亚基。 [RefSeq 提供，2008 年 7 月]

2008年6月1日 · DPM and DPG are synthesized on the cytosolic face of the ER from dolichol-phosphate (Dol-P) and GDP-Man or UDP-Glc, respectively, flip-flop into the ER lumen through putative flippases and are exclusively utilized on the luminal side.

Dolichol-phosphate mannose (Dol-P-Man) 作为内质网 (ER) 腔侧甘露糖基残基的供体。 缺乏 Dol-P-Man 会导致 GPI 锚定蛋白的表面表达缺陷。 Dol-P-Man 由 GDP-甘露糖和多萜醇磷酸在 ER 的胞质侧通过多萜醇磷酸甘露糖基转移酶合成。 人 DPM1 缺乏羧基末端跨膜结构域和信号序列，受 DPM2 调控。 该基因的突变与 Ie 型糖基化先天性疾病有关。 可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 11 月]

Dolichol phosphate-mannose synthase (Dol-P-Man synthase), which generates dolichol phosphate-mannose (Dol-P-Man) from GDP-mannose (GDP-Man) and dolichol phosphate (Dol-P), is an essential enzyme for all eukaryotic cells.

Direct genetic evidence is presented that dolichol phosphate mannose (Dol-P-Man) synthase, which transfers mannose from GDPMan to the polyisoprenoid dolichol phosphate, is required in vivo for all three biosynthetic pathways leading to these covalent modifications of …

2023年7月14日 · Farnesyl pyrophosphate (FPP) and isopentenyl pyrophosphate (IPP) are key mevalonate pathway intermediates required for the synthesis of squalene, sterols, as well as Dol (see Fig. 1). This article focuses on Dol metabolism and its role and requirement in retinal physiology, specifically as pertains to protein glycosylation.

2008年2月15日 · During protein N-glycosylation, dolichyl pyrophosphate (Dol-P-P) is discharged in the lumenal monolayer of the endoplasmic reticulum (ER). Dol-P-P is then cleaved to Dol-P by Dol-P-P phosphatase (DPPase). Studies with the yeast mutant cwh8Delta, lacking DPPase activity, indicate that recycling of Do …

De novo synthesis of dolichol (Dol) and dolichyl phosphate (Dol-P) is essential for protein glycosylation. Herein, we provide a brief overview of Dol and Dol-P synthesis and the maintenance of their cellular content.