靶向H3K79甲基化转移酶DOT1L治疗MLL基因重排型白血病
2022年4月22日 · 研究已证实dot1l参与了mll融合驱动的白血病发生。dot1l可以与融合蛋白af9、af10、enl等作用；参与调控rna pol ii相关转录延长复合体eaps、aep等蛋白复合物的功能；此 …
Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL ...
2022年3月24日 · Disrupting the methylation of telomeric silencing 1-like (DOT1L)-mediated histone H3 lysine 79 has been implicated in MLL fusion-mediated leukemogenesis. Recently, …
Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL ...
2022年3月24日 · Disrupting the methylation of telomeric silencing 1-like (DOT1L)-mediated histone H3 lysine 79 has been implicated in MLL fusion-mediated leukemogenesis. Recently, …
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9 …
2011年6月23日 · Here we demonstrate using a tamoxifen-inducible Cre-mediated loss of function mouse model that DOT1L, an H3K79 methyltransferase, is required for both initiation and …
DOT1L, the H3K79 methyltransferase, is required for MLL …
2011年6月6日 · Our study not only provides the first in vivo evidence for the function of DOT1L in leukemia, but also reveals the molecular mechanism for DOT1L in MLL-AF9 mediated …
DOT1L: a key target in normal chromatin remodelling and in …
MLL-AF10 and MLL-ENL recruit DOT1L on DNA, inducing hypermethylation of H3K79 in MLL-r target genes such as HOXA and MEIS1. To overcome the drawbacks of conventional …
DOT1L O-GlcNAcylation promotes its protein stability and MLL …
2021年9月21日 · DOT1L is a versatile histone H3K79 methyltransferase with a prominent role in MLL-fusion leukemia, yet little is known about how DOT1L responds to extracellular stimuli. …
Complementary activities of DOT1L and Menin inhibitors in MLL …
2016年11月14日 · Recently developed small-molecule inhibitors of DOT1L, such as EPZ004777, SGC0946 and EPZ-5676, block H3K79 methylation, inhibit MLL-fusion target genes and …
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain …
2015年3月30日 · DOT1L inhibits chromatin localization of a repressive complex composed of SIRT1 and the H3K9 methyltransferase SUV39H1, thereby maintaining an open chromatin …
The emerging roles of DOT1L in leukemia and normal development
2014年5月23日 · Dot1L knockout is embryonic lethal in mice and is important for processes as diverse as proliferation of mouse embryonic stem cells, induced and natural reprogramming, …