Coexpression of E2F1 and DP1 blocks ARF-induced relocalization of either subunit to the nucleolus. The E2F1/DP1 complex localizes in the nucleoplasm, whereas ARF is detected in the nucleolus, suggesting that ARF does not interact with the E2F1/DP1 complex. Moreover, we show that E2F1 is more stable in the presence of ARF when coexpressed with DP1.

2023年6月30日 · The TFDP1 gene codes for the heterodimeric partner DP1 of the transcription factor E2F. E2F, principal target of the tumor suppressor pRB, plays central roles in cell proliferation by activating a group of growth-related genes. E2F also mediates tumor suppression by activating tumor suppressor genes …

2018年5月31日 · To determine the role of DP proteins in the induction of ARF gene expression and apoptosis by deregulated E2F, we established shRNA-mediated knockdown of DP1 expression in human normal...

2023年6月30日 · The TFDP1 gene codes for the heterodimeric partner DP1 of the transcription factor E2F. E2F, principal target of the tumor suppressor pRB, plays central roles in cell proliferation by activating a group of growth-related genes.

2018年5月31日 · The transcription factor E2F plays crucial roles in cell proliferation and tumor suppression by activating growth-related genes and pro-apoptotic tumor suppressor genes, respectively. It is generally accepted that E2F binds to target sequences with its heterodimeric partner DP. Here we show that, wh …

2021年9月3日 · DP1 flexibility may be relevant for protein–protein and protein-DNA interactions. The E2F1 transcription factor is a master regulator of cell-cycle progression whose uncontrolled activation contributes to tumor cells growth.

2012年7月6日 · DP1, a dimerization partner protein of the transcription factor E2F, is known to inhibit Wnt/β‐catenin signalling along with E2F, although the function of DP1 itself was not well characterized. Here, we present a novel dual regulatory mechanism of Wnt/β‐catenin signalling by DP1 independent from E2F.

2005年12月16日 · Here we demonstrate a high-affinity interaction between RbC and E2F-DP heterodimers shared by all Rb and E2F family members. The crystal structure of an RbC-E2F1-DP1 complex reveals an intertwined heterodimer in which the marked box domains of both E2F1 and DP1 contact RbC.

转录因子 dp-1： 该基因编码转录因子家族的一个成员，这些转录因子与 e2f 蛋白异二聚化以增强其 dna 结合活性并促进 e2f 靶基因的转录。 编码的蛋白质作为该复合物的一部分起作用，以控制参与从 G1 期到 S 期的细胞周期进展的众多基因的转录活性。

我们在这里报告说，DP-1和E2F-1存在于体内的DNA结合复合物中，它们作为E2F位点的异源二聚体有效且优先结合。 此外，对酵母和果蝇细胞的研究表明，DP-1和E2F-1在E2F位点依赖性转录激活中协同相互作用。 普遍认为，细胞转录因子DRTF1 / E2F将细胞周期事件与转录装置整合在一起，因为在哺乳动物细胞的细胞周期进程中，它与重要的细胞增殖调节剂分子（例如成视网膜细胞瘤肿瘤抑制基因产物（pRb））相互作用），p107，细胞周期蛋白和细胞周期蛋白依赖性激酶。 …