2006年2月20日 · Background: Dermal papilla cells (DPC) are a group of mesenchyme-derived cells at the base of the hair follicle, where they regulate and control hair follicle growth through the expression and secretion of cytokines. Nevertheless, the role of DPC derived chemokines and other cytokines in the hair follicle biology remain speculative.

Human Hair Follicle Dermal Papilla Cells (HFDPC) are mesenchymal cells isolated from the hair papilla of normal human scalp hair follicles. Hair papilla, in the adult hair follicle, plays a crucial role in the dermal-epidermal interactions that control hair production and events of …

2018年12月13日 · Overexpression of Lef-1 in dermal papilla cells (DPC) restores the intact DPC transcriptional signature and significantly enhances the efficiency of HF...

Dermal papilla cells (DPCs) are specialized mesenchymal component of hair that play crucial role in morphogenesis and regeneration of hair growth. DPCs regulate the HF development and growth by acting as a reservoir of multi-potent stem cells, nutrients and growth factors 8.

2024年10月20日 · Dermal papilla cells (DPCs) exhibit stem cell properties and show significant potential for use in cell therapy. They can be induced into other functional cells, regenerate skin tissues and new hair follicles when combined with epithelial stem cells, and promote hair growth and wound healing when administered on the skin.

最新研究显示DPC至少有4个细胞亚群,分别诱导单谱系瞬时扩增上皮细胞形成多层同心圆排列的毛干与毛鞘。 还发现持续的心理应激可导致支配隆突区的交感神经过度活跃,交感神经末梢释放大量的去甲肾上腺素可诱导MeSC快速增殖,导致MeSC库耗竭和毛干色素脱失。 通过对DPC促毛发生长和黑素生成的分子调节机制的认识,有望在体外大规模培养DPC用于细胞移植治疗人类秃发疾病。

2020年12月1日 · The induction of dermal fibroblasts into DPC-like cells through biomimetic microencapsulation, devoid of chemical or gene reprogramming, would provide an alternative, abundant, and safe source of DPCs, which would help circumvent the bottleneck in DPC-based HF regeneration.

真皮乳头间叶细胞，外文名dermal papillary cell。 真皮乳头间叶细胞 [1] 又叫DP细胞，位于毛囊底部，它有个很独特的作用，就是能诱导头发形成。 头发的生长取决于发根的毛囊细胞，头发从生长期过度到休止期至少需要三个月的时间，期间位于毛囊底部的真皮乳头间叶细胞（DP）是联系和控制整个毛囊细胞群的核心，是帮助合成新发和传输养分的部分，也是帮助毛母细胞分裂合成新发的关键。 [2] 如果DP细胞发生分子断裂，就会造成毛囊内部环境恶化，出现发根 营养不良，抑 …

2023年2月16日 · In this study, we found that DPC-Exos increase ki67 expression and CCK8 cell viability readouts in HFSCs but reduce annexin staining of apoptotic cells. RNA sequencing of DPC-Exos-treated HFSCs identified 3702 significantly differentially expressed genes (DEGs), including BMP4, LEF1, IGF1R, TGFβ3, TGFα, and KRT17. These DEGs were enriched in ...

2018年6月2日 · Background: Dermal papilla cells (DPCs) play a critical role in the regulation of hair follicle (HF) growth, formation, and cycling. DPCs are thought to regulate HF growth through a paracrine mechanism, in which exosomes may play a critical role.