白介素6（interleukin 6，IL-6），是与炎症相关最为典型的细胞因子。 它通过调节免疫和炎症反应，在宿主防御中发挥着重要作用。 今天，小E就来和大家聊聊，IL-6的起源、特性、功能与应用。

HLA-DQ6 (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the antibody recognition of β 6 subset of DQ β-chains. The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and …

IL-6 is a soluble mediator with a pleiotropic effect on inflammation, immune response, and hematopoiesis. At first, distinct functions of IL-6 were studied and given distinct names based on their biological activity.

2022年10月1日 · IL-6 is a cornerstone in B cell maturation and antibody production. IL-6 dysregulation underlies inflammatory, autoimmunity, and cancer pathogenesis. IL-6 inhibitors offer hope to patients with autoimmune and inflammatory conditions. Tocilizumab and Sarilumab are promising in COVID-19 cytokine storm management.

IL-6 is a cytokine with a number of different functions that plays a role in the host acute response to inflammation; it modulates host defence through numerous different mechanisms and actions directed towards monocytes, B cells and controlling homeostasis between Th1 and Th2 activity (75 …

IL-6结合受体有两种，一种是特异性受体 IL-6R （80kDa I型跨膜蛋白），另一种是gp130，是IL-6家族细胞因子的所有成员的常见受体亚单位。gp130可以在所有细胞表达，但IL-6R的表达受到更多的限制，主要发现于肝细胞、嗜中性粒细胞、单核细胞和CD4+ T细胞。

Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both pro-inflammatory and anti-inflammatory activity, depending on the immune response context. Macrophages are among several cells that secrete IL-6, which they express upon activation by antigens, subsequently …

IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely related to chronic inflammatory diseases, autoimmune diseases and cancer) and even in the cytokine storm of corona virus disease 2019 (COVID-19).

2024年4月1日 · IL-6 monoclonal antibodies are a specific class of monoclonal antibodies designed to target and block the activity of interleukin-6 (IL-6), a pro-inflammatory cytokine. IL-6 is involved in various immune responses and plays a critical role in …

Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans. IL-6 signaling is mediated by building a …

2020年3月1日 · Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates its biological roles through a hexameric complex composed of IL-6 itself, its receptor IL-6R, and glycoprotein 130 (IL-6/IL …

il-1β的局部激活是介导促炎反应的中心环节，导致继发性炎症介质（包括il-6）的激活。反过来，il-6系统性地作用于肝脏产生急性期蛋白，如全c反应蛋白（crp）、纤维蛋白原和纤溶酶原激活物抑制剂。

2021年5月27日 · 敌草快（diquat，DQ），化学名称为1，1'-亚乙基-2，2'-联吡啶阳离子或二溴盐，分子式为C 12 H 10 Br 2 N 2，与百草枯（paraquat，PQ）同属联吡啶类除草剂，被用作接触干燥剂和采前干燥剂来控制陆地和水生植被，可以通过消化道、呼吸道、皮肤黏膜接触等途径吸收，在脾脏中分布最高，在肾脏中次之。 其急性中毒的主要临床表现为消化系统、呼吸系统、循环系统、泌尿系统、中枢神经系统等多系统脏器损伤 [1]。 自2016年7月我国禁用PQ以来，DQ中 …

2023年1月1日 · The HLA-DQ-knockdown group had lower concentrations of Th1-type lymphokines (IL-2, IFN-γ, and TNF-α) and similar concentrations of Th2-type lymphokines (IL-4, IL-6, and IL-10). It may suggest that HLA-DQ can directly or indirectly promote the activation of CD4 + T cells and the polarization of Th1 cells.

Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro- and anti-inflammatory properties. Although only small amounts in the picogram range can be detected in healthy humans, IL-6 expression is highly and transiently up-regulated in …

Interleukin-6 (IL-6) is considered one of the most prominent pro-inflammatory cytokines 1. Blockade of IL-6 by the neutralising monoclonal antibody tocilizumab has been approved in more than 100 countries for the treatment of patients with …

2022年2月25日 · 白介素6（interleukin 6，IL-6），是与炎症相关最为典型的细胞因子。 它通过调节免疫和炎症反应，在宿主防御中发挥着重要作用。 现在就来和大家聊聊，IL-6的起源、特性、功能与应用。

This review recapitulates general aspects of IL-6 signaling and summarizes experimental evidences about IL-6 involvement in the etiopathogenesis of IgA nephropathy through the production of Gd-IgA1 and regulation of mesangial cell proliferation.

Sepsis, a life-threatening condition arising from a dysregulated immune response to infection, is a significant health burden globally. Interleukin-6 (IL-6), an inflammatory cytokine produced by immune cells as a response to infection and tissue damage, plays a key role in the pathogenesis of sepsis. This systematic review and meta-analysis aimed to …

Interleukin-6 (IL-6) is a pleiotropic cytokine with complex roles in inflammation and metabolic disease. While typically regarded as a pro-inflammatory cytokine, multiple studies in the last 20 years have generated conflicting data on the role of IL-6 in inflammation and metabolism.