Dopamine receptor D 2, also known as D 2 R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard 's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to ...

2024年12月24日 · DRD2 (Dopamine Receptor D2) is a Protein Coding gene. Diseases associated with DRD2 include Dystonia 11, Myoclonic and Major Depressive Disorder. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs.

多巴胺受体家族属于 G蛋白 （由Gα和Gβγ三个亚基组成）偶联受体超家族（G-Protein-Coupled Receptor， GPCR），包含五个成员：DRD1、 DRD2 、DRD3、DRD4和DRD5。 其中，DRD1和DRD5属于D1类受体，与激活型G蛋白Gs偶联，刺激第二信使 cAMP 的产生；而DRD2、DRD3和DRD4属于D2类受体，与抑制型G蛋白Gi/o偶联，抑制第二信使cAMP的生成。 其中， 多巴胺受体D2 （DRD2）是精神分裂症和帕金森综合症的主要靶点。 此前，DRD2结合精神分裂症药物 利 …

Gene ID: 1813, updated on 8-Feb-2025. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have …

It is hypothesised that the DRD2 is a reinforcement or reward gene. Although less intensively studied than substance use disorders, the DRD2 gene has been implicated in Tourette's syndrome (TS), post-traumatic stress disorder (PTSD) and certain symptoms associated with affective disorders and schizophrenia.

该基因编码多巴胺受体的 D2 亚型。 这种 G 蛋白偶联受体抑制腺苷酸环化酶活性。 该基因的错义突变导致肌阵挛性肌张力障碍；其他突变与精神分裂症有关。 该基因的可变剪接导致编码不同亚型的两个转录变体。 已经描述了第三种变体，但尚未确定这种形式是正常的还是由于异常剪接。 [RefSeq 提供，2008 年 7 月] This gene encodes the D2 subtype of the Dopamine Receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity.

2020年6月11日 · DRD2 is activated by the endogenous neurotransmitter dopamine and synthetic agonist drugs such as bromocriptine 3, leading to stimulation of G i and inhibition of adenylyl cyclase. Here we used...

2025年2月8日 · Title: DRD2 activation inhibits choroidal neovascularization in patients with Parkinson's disease and age-related macular degeneration. Receptor density influences ligand-induced dopamine D2L receptor homodimerization.

2025年1月4日 · Clinical resource with information about DRD2, Biological insights from 108 schizophrenia-associated genetic loci., Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus., Genome-wide association with select biomarker traits in the Framingham Heart ...

2017年7月13日 · What is DRD2? The dopamine D2 receptor, encoded by the DRD2 gene, plays a critical role in response to antipsychotic medications. All antipsychotic medications bind to the D2 receptor, underscoring its importance in treating psychotic symptoms.