The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5. [5] The structure of DRD4 has been reported in complex with the antipsychotic drug nemonapride. [6] As with other dopamine receptor subtypes, the D 4 receptor is activated by the neurotransmitter dopamine.

2019年9月13日 · DRD4 is the gene that codes for the building of the Dopamine 4 receptor, a G Protein usually found on the postsynaptic membrane throughout the mesocorticolimbic projections. There are multiple...

2024年12月24日 · DRD4 (Dopamine Receptor D4) is a Protein Coding gene. Diseases associated with DRD4 include Attention Deficit-Hyperactivity Disorder and Autonomic Nervous System Disease. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

多巴胺受体D4是一种由 DRD4基因 编码的G蛋白偶联受体。 和其他多巴胺受体亚型一样，D4受体由神经递质——多巴胺激活。 它与 精神分裂症, 帕金森症, 躁郁症，上瘾行为，以及诸如厌食症, 贪食症和暴食症等神经性进食紊乱症等许多神经学或心理学状况相关。 此受体也是许多治疗精神分裂症和帕金森症的靶标. D4受体被认为与D2-类似，被激活的受体抑制腺甙酸环化酶，从而减少细胞内第二信息递质环磷腺苷的浓度。 此人体蛋白由 11号染色体上位于11p15.5的基因DRD4编码。 …

The human dopamine receptor D4 (DRD4) gene, located near the telomere of chromosome 11p, exhibits an unusual amount of expressed polymorphism. It contains a 48-bp Variable Number Tandem Repeat (VNTR) polymorphism in the third exon [ 11 ], repeated between 2 and 11 times, with the most common versions being 2 (2R), 4 (4R) and 7 (7R) repeats.

2025年2月8日 · Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking.

We review the evidence conveying a significant and differential role of D 4.4 R and D 4.7 R in the dopaminergic and noradrenergic modulation of the frontal cortico-striatal pyramidal neuron, with implications for the moderation of constructs of impulsivity as personality traits.

2012年6月12日 · In the present study, we assess the potential influence of cis -acting genetic polymorphisms in mediating DNA methylation at 9 CpG sites across the DRD4 promoter region, using lymphoblastoid cell-lines from a familial sample, and post-mortem brain tissue from an independent set of individuals.

Gene ID: 1815, updated on 8-Feb-2025. This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease.

Among the dopamine-related genes investigated to date, the dopamine receptor D4 (DRD4) gene has been widely studied and it is the candidate gene with the strongest association with ADHD in different meta-analysis studies [4]. The most investigated polymorphism is a …