Donor specific antibodies made easy - Renal Fellow Network
2022年3月12日 · Donor specific Antibodies (DSA) are one of the established biomarkers for predicting antibody mediated rejection (ABMR). This blog is a short synopsis on DSA and their …
肾移植人类白细胞抗原分型和抗体检测专家共识 - 中华医学杂志
移植前预致敏患者体内的预存DSA（preformed DSA，pfDSA）可诱发超急性排斥反应、加速急性排斥反应和早期活动性抗体介导的排斥反应（active AMR，aAMR）；移植后新 …
High Mean Fluorescence Intensity Donor-Specific Anti-HLA …
Highest mean fluorescent intensity (MFI) donor-specific antibody (DSA) for (A) preformed class I (mean MFI 4075 vs. 1027), (B) preformed class II (mean MFI 2849 vs. 1209), (C) post-OLT …
中国肾脏移植免疫监测临床诊疗指南（2023版） - 中华器官移植杂志
单抗原微珠法检测DSA的水平采用MFI值来表示，但不同移植中心判读DSA阳性的MFI阈值并不一致。 目前国内、外大部分HLA实验室以MFI值等于1 000作为抗体阳性的判读阈值 [19, 20]，也 …
Interpreting Anti-HLA Antibody Testing Data: A Practical Guide for ...
Understanding the complexities and limitations of DSA detection techniques is key for making an accurate risk assessment while improving access to transplantation. The goal of this overview …
Cumulative donor-specific antibody threshold predicts platelet ...
2024年8月30日 · In severe HLA-alloimmune platelet transfusion refractoriness, DSA-MFI sums >10 000 and major-ABO mismatch actionably predict poor 2-hour CCI. Computer-aided …
Donor-Specific Anti-HLA Antibodies in Haploidentical Stem Cell ...
The presence of donor-specific anti-HLA antibodies (DSA) is associated with a 10-fold increased risk of graft failure in haploidentical stem cell transplantation (haplo-SCT). Consensus …
Engraftment outcome of patients with anti-HLA antibodies in HLA ...
3 天之前 · In the high DSA group, two patients received a DSA-depleting intervention. Only one patient with an MFI of 5832 (without intervention) developed primary graft failure, while the …
Impact of donor-specific antibody with low mean fluorescence …
2024年6月1日 · Exposure to alloantigen, including human leukocyte antigen (HLA), results in the production of donor-specific antibodies (DSA). There are limited data about low levels of mean …
Donor-Specific Antibodies in Kidney Transplant Recipients
Donor-specific antibodies (DSAs) identified before kidney transplant (preformed DSAs) can cause early rejection, such as hyperacute rejection, accelerated acute rejection, early acute antibody …