Donor specific antibodies made easy - Renal Fellow Network
Mar 12, 2022 · Donor specific Antibodies (DSA) are one of the established biomarkers for predicting antibody mediated rejection (ABMR). This blog is a short synopsis on DSA and their complex characteristics in kidney transplantation. DSA may be preformed (before transplantation) or de-novo (developing after transplantation).
肾移植人类白细胞抗原分型和抗体检测专家共识 - 中华医学杂志
移植前预致敏患者体内的预存DSA（preformed DSA，pfDSA）可诱发超急性排斥反应、加速急性排斥反应和早期活动性抗体介导的排斥反应（active AMR，aAMR）；移植后新生DSA（denovo DSA，dnDSA）与晚期AMR、慢性活动性抗体介导的排斥反应（chronic active AMR，caAMR）和 …
中国肾脏移植免疫监测临床诊疗指南（2023版） - 中华器官移植杂志
肾脏移植术后HLA-DSA包括预存DSA和新生DSA（de novo DSA，dnDSA）2大类，根据2019年国际移植学会专家共识 及2022年《肾移植后期抗体介导排斥反应防治专家共识》 ：肾脏移植术后30 d内发生的AMR定义为早期AMR，30 d后发生的AMR称为后期AMR，尽管预存DSA也可能参与介导 …
Impact of donor-specific antibody with low mean fluorescence …
Jun 1, 2024 · Exposure to alloantigen, including human leukocyte antigen (HLA), results in the production of donor-specific antibodies (DSA). There are limited data about low levels of mean fluorescence intensity (MFI) DSA, especially post-transplantation. This study evaluated allograft outcomes in KT patients with low MFI DSA.
High Mean Fluorescence Intensity Donor-Specific Anti-HLA …
Highest mean fluorescent intensity (MFI) donor-specific antibody (DSA) for (A) preformed class I (mean MFI 4075 vs. 1027), (B) preformed class II (mean MFI 2849 vs. 1209), (C) post-OLT class I (mean MFI 1858 vs. 600) and (D) post-OLT class II (mean MFI 9930 vs. 3637). + represents each patient’s maximum value, line represents the group’s ...
Cumulative donor-specific antibody threshold predicts platelet ...
Aug 30, 2024 · In severe HLA-alloimmune platelet transfusion refractoriness, DSA-MFI sums >10 000 and major-ABO mismatch actionably predict poor 2-hour CCI. Computer-aided histocompatibility ranking to lower DSA-MFI sums may streamline donor …
Donor-Specific Antibodies in Kidney Transplant Recipients
Donor-specific antibodies (DSAs) identified before kidney transplant (preformed DSAs) can cause early rejection, such as hyperacute rejection, accelerated acute rejection, early acute antibody-mediated rejection, and graft loss (1 – 6).
Donor-Specific Anti-HLA Antibodies in Haploidentical Stem Cell ...
The presence of donor-specific anti-HLA antibodies (DSA) is associated with a 10-fold increased risk of graft failure in haploidentical stem cell transplantation (haplo-SCT). Consensus guidelines from the European Society for Blood and Marrow Transplantation set a mean fluorescence intensity (MFI) & …
Understanding solid-phase HLA antibody assays and the value of MFI
The reporting of HLA antibody activity as mean fluorescence intensity (MFI) values has led to an incorrect perception that those values represent the “strength” of the antibodies, including donor specific antibodies (DSA). Clinicians use preset MFI thresholds as decision points pre-and post-transplant to determine the necessity of pre-or ...
Low-MFI (median fluorescence intensity) pre-transplant DSA …
Dec 1, 2023 · We present two cases of LDKT (low-MFI pre-transplant DSA) who presented with early ABMR as a result of an anamnestic antibody response (DSA against HLA class II antibodies) confirmed by retesting with both pre-transplant (archived) and post-transplant patients' samples and freshly obtained donor samples.