A double-strand break repair model refers to the various models of pathways that cells undertake to repair double strand-breaks (DSB). DSB repair is an important cellular process, as the accumulation of unrepaired DSB could lead to chromosomal rearrangements, tumorigenesis or even cell death. [1]

在ddr中，atm负责协调细胞对dsb（双链断裂）的应答，包括dna修复、检查点激活、凋亡、衰老以及染色质结构改变、转录和mrna剪接等。 它是一种顶端激酶，可以响应DNA损伤而使数百种底物磷酸化。

2019年7月1日 · In this Review, we consider DSB repair-pathway choice in somatic mammalian cells as a series of ‘decision trees’, and explore how defective pathway choice can lead to genomic instability....

Cells repair DNA double-strand breaks (DSBs) through a complex set of pathways critical for maintaining genomic integrity. To systematically map these pathways, we developed a high-throughput screening approach called Repair-seq that measures the effects of thousands of genetic perturbations on mutations introduced at targeted DNA lesions.

DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity. Failure to repair a DSB has deleterious consequences, including genomic instability and cell death. Indeed, misrepair of DSBs can lead to inappropriate end-joining events, which commonly underlie oncogenic transformation due to chromosomal translocations.

2019年4月18日 · DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel of 18 rodent species with diverse lifespans, we show that more robust DNA double-strand break (DSB) repair, but not nucl …

2025年3月17日 · Once assembled, DSB repair foci resemble biomolecular condensates, which are membrane-less organelles that selectively concentrate molecules involved in DNA repair around damaged areas of the ...

2023年6月19日 · DNA双链断裂（DNA double-strand break，DSB）是一种常见且高度有害的DNA损伤形式，严重威胁着基因组稳定性和细胞存活。DSB修复缺陷或失调与肿瘤、衰老以及免疫缺陷等密切相关。

In this Review, we consider DSB repair-pathway choice in somatic mammalian cells as a series of 'decision trees', and explore how defective pathway choice can lead to genomic instability. Stalled, collapsed or broken DNA replication forks present a distinctive challenge to …

2025年2月12日 · Regulating DNA double-strand break (DSB) repair pathway choice is a finely tuned process determining cellular outcomes following DNA damage. Cells navigate complex signaling pathways and protein interactions to select the most appropriate repair mechanism, influenced by factors including the cell cycle stage, DNA end nature, and genomic context.