DNA double-strand break repair-pathway choice in somatic …
2019年7月1日 · In this Review, we consider DSB repair-pathway choice in somatic mammalian cells as a series of ‘decision trees’, and explore how defective pathway choice can lead to …
Review
2012年8月24日 · Here, we review recent insights into the mechanisms that influence the choice between competing DSB repair pathways, how this is regulated during the cell cycle, and how …
Homologous recombination in DNA repair and DNA damage …
2008年1月1日 · Homologous recombination (HR) is a DNA metabolic process found in all forms of life that provides high-fidelity, template-dependent repair or tolerance of complex DNA …
DNA double-strand break repair in cancer: A path to
2021年1月1日 · This review comprises a brief overview of the DSB repair mechanisms in cancer and includes results obtained with revolutionary advances such as CRISPR/Cas9 and …
Double-strand break repair: 53BP1 comes into focus - Nature Reviews …
2013年12月11日 · In this Review, we highlight 53BP1 as a mediator and effector of the DSB response. In particular, we focus on a flurry of discoveries that have shed light on how 53BP1 …
Understanding the DNA double-strand break repair and its …
2021年10月1日 · In the present review, we highlight the different mechanisms of DSB repair, chromatin dynamics to provide repair accessibility and modulation of inhibitors in association …
DNA double-strand break repair-pathway choice in somatic mammalian ...
In this Review, we consider DSB repair-pathway choice in somatic mammalian cells as a series of 'decision trees', and explore how defective pathway choice can lead to genomic instability. …
DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics
Among DNA damages, double-strand breaks (DSBs) are one of the most harmful lesions to a cell. Failure in DSB repair could lead to genomic instability and cancer. Homologous recombination …
DNA double-strand breaks repair in cancer: A path to achieving ...
This review comprises a brief overview of the DSB repair mechanisms in cancer and includes results obtained with revolutionary advances such as CRISPR/Cas9 and machine …
Mechanism and Control of Meiotic DNA Double-Strand Break ... - PubMed
2021年3月2日 · Developmentally programmed formation of DNA double-strand breaks (DSBs) by Spo11 initiates a recombination mechanism that promotes synapsis and the subsequent …