2014年2月4日 · Among various chemically induced colitis models, the dextran sulfate sodium (DSS)-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that must be considered when employed.

Perhaps the most widely used mouse model of colitis employs dextran sodium sulfate (DSS), a chemical colitogen with anticoagulant properties, to induce disease. DSS is a water-soluble, negatively charged sulfated polysaccharide with a highly variable molecular weight ranging from 5 …

2021年3月5日 · Both younger and older mice treated with acute or chronic dextran sodium sulfate (DSS) developed colitis, which was evidenced by weight loss, colon length shortening, and elevated disease...

2021年11月10日 · Results: DSS-treated mice exhibited clinical hallmarks of colitis, including weight loss, colonic shortening and inflammation in the colon. We also detected a significant increase in inflammatory cytokines in the serum and brain, as well as caspase and microglia activation in the brain of mice with ongoing colitis.

Dextran sodium sulfate (DSS)-induced colitis mouse model is used for research of inflammatory bowel disease. The aim of this study was to establish the adequate conditions for DSS mice model, and to find useful tool to measure inflammation. The 2.5% DSS was administered to six male C57BL/6 mice and 4% DSS to eight mice at 5 or 9 weeks of age.

2024年1月27日 · Colitis induced by DSS presents indiscriminate epithelial cell damage and extensive microbial invasion into the lamina propria, which are unlikely to occur in human IBD. 93 The difference between DSS colitis and human IBD is also reflected in the observation that DSS-induced chronic colitis is associated with mixed T-cell pro-inflammatory ...

2020年3月2日 · Impact of CS exposure on DSS-induced colitis. DSS-treated mice developed colitis, as evidenced by weight loss (Fig. 2A), increased colon weight/length ratio (Fig. 2B), and the disease...

2010年3月4日 · The dextran sulphate sodium (DSS) model of colitis is widely perceived as a good model of experimental colitis because it has similarities to human IBD in aetiology, pathology, pathogenesis and therapeutic response.

DSS induced colonic inflammation can be adapted as acute, chronic or relapsing model of intestinal inflammation by changing the concentration, duration and cycles of administration of DSS in drinking water. In this protocol, we provide a detailed description of procedures, important considerations when performing the protocol.

Dextran sodium sulfate (DSS)-induced colitis is an inflammatory bowel disease model and is characterized by infiltration of inflammatory cells into the lamina propria, lymphoid hyperplasia, epithelial ulceration and focal crypt damage.