2023年7月10日 · Various functional characterization markers including CD44, CD62L, TIGIT, CD226, PD-1, ICOS, Helios, CTLA-4 and Bcl6 were analyzed in the T cell subsets of the organs. Tfh and Tfr cells in the colon were significantly increased in DSS-colitis mice.

2019年7月11日 · Mechanisms underlying fibrogenesis in chronic colitis are largely unknown. There is an urgent need for clinical markers and identification of targets to prevent, treat and limit intestinal fibrosis.

Galectin-3 offers protection from inflammation in experimental colitis. Galectin-3 knockout mice have more severe disease activity in DSS-induced colitis. Adoptive transfer of galectin-3-treated T cells reduced bowel inflammation. Galectin-3 inhibited colonic mucosa inflammation by …

Levels of ICOS on CD4+ T-cells from the spleen and colonic lamina propria were significantly upregulated after Concanavalin A (Con A) stimulation. In addition, ICOS was also upregulated on CD4+ T-cells from DSS-fed rats compared with those from non DSS-fed rats.

2021年12月1日 · Dextran sodium sulfate (DSS)-induced colitis is a well-established model of intestinal inflammation that expresses important histological and biochemical features of human UC. [2] The occurrence and development of UC are related to T cell dysfunction, mainly manifested as the imbalance of T-helper 17/T regulatory (Th17/Treg) cells. [3]

在器官的 T 细胞亚群中分析了各种功能特征标记，包括 CD44、CD62L、TIGIT、CD226、PD-1、ICOS、Helios、CTLA-4 和 Bcl6。 结果：DSS 结肠炎小鼠结肠中的 Tfh 和 Tfr 细胞显着增加。

2023年2月28日 · Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including tumor cells in the tumor microenvironment) [16, 17].

2004年3月1日 · In the present study, the authors investigated the involvement of ICOS in the development of rat dextran sulfate sodium (DSS)-induced colitis, and the therapeutic potential of anti-ICOS...

2004年2月1日 · Inducible co‐stimulator (ICOS), which is up‐regulated on T cells upon activation, engages the novel B7rp1 counter‐receptor on antigen‐presenting cells (APC) (11, 12). Stimulation through ICOS was shown to augment IL‐2, IL‐4, IL‐5, IFN‐γ and tumor necrosis factor production similar to CD28 co‐stimulation (11, 13).

2021年12月21日 · Follicular helper T cells (Tfh) regulate the differentiation of germinal center B cells and maintain humoral immunity. Notably, imbalances in Tfh differentiation often lead to the development of autoimmune diseases, including inflammatory bowel disease (IBD).