Doublesex (dsx) is a gene that is involved in the sex determination system of many insects including the fruit fly Drosophila melanogaster. The gene is expressed in both male and female flies and is subject to alternative splicing, producing the protein isoforms dsxf in females and the longer dsxm in males.

2019年5月8日 · doublesex (dsx) is a transcription factor that regulates the last step of sex differentiation in all holometabolous insects during early development (8 – 10).

2015年8月17日 · The doublesex (dsx) gene functions as a molecular switch at the base of the insect sex determination cascade and triggers male or female somatic sexual differentiation in...

2022年7月22日 · In this study, we report that intron retention (IR) generates a male-specific dsx transcript and propose an evolutionary pathway from sexually monomorphic to sex-specific splicing of dsx. We...

2022年9月19日 · doublesex (dsx)就是这样一个高度保守的性别调控基因，其与同源的Dmrt基因均编码包含保守的DNA结合域的转录因子，决定了几乎所有已有研究物种的性别分化。

Here we show that the doublesex (dsx) gene, which expresses male-specific Dsx M and female-specific Dsx F transcription factors, functions in the nervous system to control both male and female sexual and aggressive behaviors.

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and zinc ion binding activity. Involved in axon …

Sex-specific neurons play pivotal roles in regulating sexually dimorphic behaviors. In insects, the sex determination gene doublesex (dsx) establishes major sexual dimorphism of the nervous system, in which male-specific dsx M promotes neuronal development, while female-specific dsx F inhibits neuronal development by promoting neuronal apoptosis.

2010年3月21日 · Doublesex proteins, which are part of the structurally and functionally conserved Dmrt gene family, are important for sex determination throughout the animal kingdom. We...

2025年2月19日 · Sex-specific neurons play pivotal roles in regulating sexually dimorphic behaviors. In insects, the sex determination gene doublesex (dsx) establishes major sexual dimorphism of the nervous system, in which male-specific dsxM promotes neuronal development, while female-specific dsxF inhibits neuronal development by promoting neuronal apoptosis.