Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene. [5][6] The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.

2024年12月24日 · DUSP1 (Dual Specificity Phosphatase 1) is a Protein Coding gene. Diseases associated with DUSP1 include Intellectual Developmental Disorder, X-Linked 108 and Ovarian Cancer. Among its related pathways are MAPK family signaling cascades and ERK Signaling.

2023年11月7日 · Literature reports suggest that dual-specificity phosphatase 1 (DUSP1) plays a critical role in maintaining mitochondrial function and structural integrity. In this study,...

DUSP1 regulates the JAK2/STAT3 signaling pathway through targeting miR-21 in cervical cancer cells. Extracellular Heat Shock Protein 70 Increases the Glucocorticoid Receptor and Dual-Specificity Phosphatase 1 via Toll-like Receptor 4 and Attenuates Inflammation in …

该基因编码的蛋白质是一种磷酸酶，对酪氨酸和苏氨酸具有双重特异性。 编码的蛋白质可以使 MAP 激酶 MAPK1/ ERK2 去磷酸化，从而导致其参与多个细胞过程。 这种蛋白质似乎在人类细胞对环境压力的反应以及细胞增殖的负调节中发挥重要作用。 最后，编码的蛋白质可以使一些实体瘤对化学疗法和放射疗法产生耐药性，使其成为癌症治疗的靶点。 [RefSeq 提供，2017 年 8 月] The protein encoded by this gene is a Phosphatase with dual specificity for tyrosine and threonine.

2021年9月1日 · Dual specific phosphatases (DUSPs), which target MAPKs and beyond, have increasingly been emerged as a versatile regulator in T cell biology.

2023年2月14日 · DUSP1 knockdown significantly inhibited BCG-induced macrophage apoptosis and activation of MAPKs/NF-κB signaling pathway. In addition, DUSP1 knockdown suppressed BCG-induced inflammation in...

2010年10月4日 · DUSP1/MKP1 is a dual-specific phosphatase that regulates MAPKs activity, with an increasingly recognized role in tumor biology. To understand more about the involvement of DUSP1 in lung cancer,...

双特异性磷酸酶1（dual specificity phosphatase-1, DUSP1），也被称作丝裂素活化蛋白激酶磷酸酶1（mitogen-activated protein kinase phosphatase-1, MKP-1），是一种既能去磷酸化酪氨酸，又能去磷酸化苏氨酸的磷酸酶 [7]。...

2016年5月27日 · 作为苏氨酸-酪氨酸双特异性磷酸酶家族成员的双特异性磷酸酶-1（dusp1 / mkp1），首先在培养的鼠细胞中被发现。 随后通过使用基因敲除小鼠和基因沉默技术的研究，确定了DUSP1介导的细胞外信号调节蛋白激酶（ERKs）去磷酸化的分子机制。