When there is dysfunction of the mucociliary escalator, the defenses of the epithelium are markedly weakened, resulting in lung disease. The focus of this review is on the role of ciliated …

2008年1月1日 · Ciliary dysfunction is the cause of an increasing number of single organ diseases and complex syndromic forms including hydrocephalus, infertility, airway diseases,...

Research on the biology of cilia, complex hair-like cellular organelles, has greatly informed our understanding of its crucial role in respiratory health and the pathogenesis of Primary Ciliary …

2014年11月25日 · We start with an introduction to cilia structure and assembly and indicate where they are found in the human body. We then discuss the clinical features of selected …

In this review, we emphasize the importance of airway cilia in mucociliary clearance and discuss how environmental pollutants affect the structure and function of airway cilia, thus shedding …

The prototypical disorder of respiratory cilia is primary ciliary dyskinesia, an inherited disorder that leads to impaired mucociliary clearance, to repeated chest infections, and to the progressive …

What Happens If Your Cilia are Damaged? If, whether through hereditary or external factors, your cilia become damaged, your lungs will struggle to clear mucus independently. Imagine if those …

2014年11月1日 · Cilia in the human respiratory tract play a critical role in clearing mucus and debris from the airways. Their function can be affected by a number of drugs or other …

Several molecular mechanisms involved in cilia-related disorders have been identified that affect the structure and function of distinct cilia types. Defects in the function of cellular organelles …

2024年3月1日 · Ciliary dysfunction causes a large group of developmental and degenerative human diseases known as ciliopathies. These diseases reflect the critical roles that cilia play …