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Wikipedia
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DDB1 - Wikipedia
DNA damage-binding protein 1 is a protein that in humans is encoded by the DDB1 gene. The gene's position is on chromosome 11q12-q13.
Protein
The DDB1 gene encodes the large subunit of DNA damage-binding protein, a heterodimer composed of a large and a small ( 展开
Function
As its name suggests, DDB1 was initially implicated in the process of a specific type of DNA repair known as nucleotide excision repair. Since then, researchers have found that DDB1 primarily functions as a core component of the … 展开
Interactions
DDB1 has been shown to interact with Transcription initiation protein SPT3 homolog, GCN5L2, DDB2, CUL4A, CUL4B and P21. 展开
DDB1 Gene - GeneCards | DDB1 Protein | DDB1 Antibody
DDB1 is a protein coding gene involved in DNA repair and protein ubiquitination. I…
GeneCards
赵同金教授团队揭示DDB1在调控脂肪组织发育和肥胖发生中的生理作用
本文报道了赵同金教授团队发现DDB1能够通过乙酰化组蛋白阅读子BRWD3结合到 …
复旦大学代谢与整合生物学研究院
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PubMed
https://pubmed.ncbi.nlm.nih.gov
Damage-specific DNA binding protein 1 (DDB1): a protein with a …
Damage-specific DNA binding protein 1 (DDB1) is a multifunctional protein that was first isolated as a subunit of a heterodimeric complex that recognises the UV-induced DNA lesions in the …
- 作者: Barbara Iovine, Maria Luigia Iannella, Maria Assunta Bevilacqua
- Publish Year: 2011
GeneCards
https://www.genecards.org › cgi-bin › car…
DDB1 Gene - GeneCards | DDB1 Protein | DDB1 Antibody
2024年12月24日 · DDB1 is a protein coding gene involved in DNA repair and protein ubiquitination. It encodes the large subunit of the UV-DDB complex and the adaptor molecule for the CUL4 E3 ligase complex.
复旦大学代谢与整合生物学研究院
https://imib.fudan.edu.cn › page.htm
赵同金教授团队揭示DDB1在调控脂肪组织发育和肥胖 …
本文报道了赵同金教授团队发现DDB1能够通过乙酰化组蛋白阅读子BRWD3结合到最早期基因启动子上，释放Pol II暂停，开启脂肪细胞分化的转录事件。该研究揭示了DDB1在调控脂肪组织发育和肥胖发生中的生理作用，并发现了Pol II暂停释 …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
DDB1 damage specific DNA binding protein 1 [ (human)]
Results suggest that DDB1 prevents DNA lesions from accumulating in replicating human cells, in part by regulating Cdt1 degradation. the interaction with DDB1 mediates Vpr-induced …

MCE-生物活性分子大师
https://www.medchemexpress.cn › gene
损伤特异性 DNA 结合蛋白 1（DDB1）基因 | MCE
损伤特异性 DNA 结合蛋白 1：由该基因编码的蛋白质是异二聚体 DNA 损伤结合 (DDB) 复合物的大亚基 (p127) ，而另一种蛋白质 (p48) 形成小亚基。这种蛋白质复合物在核苷酸切除修复中 …
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What does DDB1 stand for?
1 Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Via S. Pansini 5, 80131 Napoli, Italy. Damage-specific DNA binding protein 1 (DDB1) is a multifunctional protein that was first isolated as a subunit of a heterodimeric complex that recognises the UV-induced DNA lesions in the nucleotide excision repair pathway.
Damage-specific DNA binding protein 1 (DDB1): a protein with a wide
pubmed.ncbi.nlm.nih.gov
What does DDB1 do?
As its name suggests, DDB1 was initially implicated in the process of a specific type of DNA repair known as nucleotide excision repair. Since then, researchers have found that DDB1 primarily functions as a core component of the CUL4A - and CUL4B -based E3 ubiquitin ligase complexes.
DDB1 - Wikipedia
en.wikipedia.org
What is a DDB1 gene?
The DDB1 gene encodes the large subunit of DNA damage-binding protein, a heterodimer composed of a large and a small (DDB2) subunit. DDB1 contains 1140 amino acids, amounting to a mass of 127 kDa. As its name suggests, DDB1 was initially implicated in the process of a specific type of DNA repair known as nucleotide excision repair.
DDB1 - Wikipedia
en.wikipedia.org
What diseases are associated with DDB1?
Diseases associated with DDB1 include White-Kernohan Syndrome and Xeroderma Pigmentosum, Complementation Group E. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA repair pathways, full network. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and damaged DNA binding.
DDB1 Gene - GeneCards | DDB1 Protein | DDB1 Antibody
genecards.org
Is DDB1 a cytosolic protein?
In un-irradiated cells, DDB1 is mostly a cytosolic protein. After UV irradiation, DDB1 translocates into the nucleus and binds DDB2 or Cockayne Syndrome Protein (CSA).
Damage-specific DNA binding protein 1 (DDB1): a protein with a wide
sciencedirect.com
Is DDB1 acetylated?
The DDB1 is acetylated and acetylation promotes DDB1 binding to CUL4. Results revealed a function independent of its transcriptional activity, as TTF-1 was found to interact with DDB1 and block its binding to CHK1, which in turn attenuated ubiquitylation and subsequent degradation of CHK1. SIRT7 inhibits TR4 degradation by deacetylation of DDB1.
DDB1 damage specific DNA binding protein 1 [ (human)]
ncbi.nlm.nih.gov
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知乎专栏
https://zhuanlan.zhihu.com
Science | 靶向蛋白降解途径突破，几乎可用于任何疾病 …
2022年11月22日 · 通过表征crbn-ddb1系统固有的构象重排，并展示三种不同的降解分子如何影响变构和新基质结合能力，我们揭示了crbn中移动药物结合tbd的构象控制如何暗中推动新底物靶向药物的治疗成功。
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Damage-specific DNA binding protein 1 (DDB1): a protein with a …
2011年12月1日 · DDB1 interacts with the Fmod and MMP-13 promoters and may function as a transcriptional partner of E2F1. DDB1 targets the replication licensing protein (Cdt1) for …
Nature
https://www.nature.com › articles
Structure of the DDB1–CRBN E3 ubiquitin ligase in …
2014年7月16日 · Here, Nicolas Thomä and colleagues present the crystal structure of DDB1–CRBN E3 ubiquitin ligase bound to thalidomide and to the related drugs lenalidomide and pomalidomide.
Nature
https://www.nature.com › articles
Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked …
2023年11月22日 · The structure shows that parts of the N- and C-terminal structural regions in AMBRA1 fold together into the highly dynamic WD40 domain and reveals how DDB1 engages …
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