2024年12月24日 · DDIT4 (DNA Damage Inducible Transcript 4) is a Protein Coding gene. Diseases associated with DDIT4 include Squamous Cell Carcinoma and Skin Atrophy. Among its related pathways are Gene expression (Transcription) and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include 14-3-3 protein binding.

2023年12月29日 · ddit4作为一个重要的调节因子，不仅能够保护细胞免受dna损伤和环境压力的伤害，还在调控细胞的生长、存活和死亡中发挥着关键作用。 对DDIT4的深入研究不仅有助于我们更好地理解细胞生理活动的调控机制，还为新药物的研发提供了先导性的示范。

DNA-damage-inducible transcript 4 (DDIT4) protein also known as protein regulated in development and DNA damage response 1 (REDD1) is a protein that in humans is encoded by the DDIT4 gene. [5][6]

DDIT4 is a mitochondrial and tumor-related protein involved in anti-tumor therapy resistance, proliferation, and invasion, etc. Its expression level increases under the stress such as chemotherapy, hypoxia, and DNA damage.

2021年7月1日 · DNA damage-inducible transcript 4 (DDIT4) is induced in various cellular stress conditions. This study was conducted to investigate expression and prognostic significance of DDIT4 protein as a...

DNA损伤诱导转录因子4 (DNA damage induced transcription factor 4，DDIT4；也称REDD1、RTP801或Dig1)是一种保守的应激反应基因，其响应多种刺激而诱导，包括缺氧、氧化应激、糖皮质激素、DNA损伤等，已被证明可以调节细胞生长、线粒体功能、氧化应激和细胞凋亡 [8]。 既往研究表明，DDIT4对缓解氧化应激引起的皮肤老化 [9]...

Ubiquitous expression in ovary (RPKM 89.7), fat (RPKM 84.2) and 25 other tissues. 预测启用 14-3-3 蛋白结合活性。 参与对病毒的防御反应； TOR 信号的负调节；和对缺氧的反应。 位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable 14-3-3 protein binding activity. Involved in defense response to virus; negative regulation of …

2019年2月12日 · DNA damage-inducible transcript 4 (DDIT4) is a protein induced by hypoxia and in response to DNA stress. Mechanistically, DDIT4 inhibits mammalian target of...

2016年11月23日 · Amongst the known upstream repressors of mTOR, the protein DNA-Damage-Inducible Transcript 4 (DDIT4) (also known as Redd1, RTP801) inhibits mTOR in response to both hypoxia and nutrient...

DNA damage-inducible transcript 4 (DDIT4) is known to participate in various cancers, including glioblastoma multiforme (GBM). However, contradictory roles of DDIT4 exist in inducing cell death and possessing anti-apoptotic functions against cancer progression. Herein, we investigated DDIT4 signalin …