2024年12月24日 · DDX17 (DEAD-Box Helicase 17) is a Protein Coding gene. Diseases associated with DDX17 include Rift Valley Fever and Actinobacillosis . Among its related pathways are Metabolism of proteins and Transport of the SLBP independent Mature mRNA .

2024年5月24日，北京大学沈涛、黎健及汤富酬共同通讯在Signal Transduction and Targeted Therapy 发表题为“DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure”的研究论文，该研究生成了心肌细胞特异性Ddx17敲除小鼠（Ddx17-cKO）、心肌细胞特异性 Ddx17 转基因小鼠（Ddx17-Tg） 以及各种心肌细胞损伤和心力衰竭（HF）模型。 DDX17在心力衰竭和心肌细胞损伤小鼠模型的心肌中下调。

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.

该基因编码一个 DEAD box 蛋白，它是一种被多种 RNA 激活的 ATP 酶，但不被 dsDNA 激活。 这种蛋白质以及由 DDX5 基因编码的蛋白质彼此之间的关系比与 DEAD 盒家族的任何其他成员之间的关系更为密切。 由于选择性剪接和使用替代翻译起始密码子，包括非 AUG (CUG) 起始密码子，该基因可以编码多种亚型。 [RefSeq 提供，2011 年 4 月] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases.

2019年12月17日 · DDX17, a DEAD-box ATPase, is a multifunctional helicase important for various RNA functions, including microRNA maturation. Key questions for DDX17 include how it recognizes target RNAs and influences their structures, as well …

2024年5月24日 · DDX17 is downregulated in the myocardium of mouse models of heart failure and cardiomyocyte injury. Cardiomyocyte-specific knockout of Ddx17 promotes autophagic flux blockage and cardiomyocyte...

2023年1月2日 · DEAD-box helicase 17 (DDX17), which is a multifunctional ATP-dependent RNA/DNA helicase and a cofactor of the Drosha-DGCR8 complex, has been shown to play vital...

DDX17 recognizes both primary sequence elements and secondary structures of RNAs. CLIP-seq analysis of DDX17-bound RNAs revealed that DDX17 recognizes mature cellular mRNAs enriched for CA- and CT-repeat elements. DDX17 is a member of the Microprocessor complex and facilitates pri-miRNA processing, but not through these repeat elements.

2025年2月8日 · DDX17 is a Sox2-binding protein in estrogen receptor-positive breast cancer; in reporter responsive (RR) cells but not reporter unresponsive (RU) cells, DDX17 enhances the tumorigenic and stem-like features of Sox2 by promoting its binding to its target genes

2019年12月17日 · DDX17, a DEAD-box ATPase, is a multifunctional helicase important for various RNA functions, including microRNA maturation. Key questions for DDX17 include how it recognizes target RNAs and influences their structures, as well …