2024年12月24日 · DDX21 (DExD-Box Helicase 21) is a Protein Coding gene. Diseases associated with DDX21 include Stomach Disease and Retinitis Pigmentosa 33 . Among its related pathways are rRNA processing in the nucleus and cytosol and RNA Polymerase I …

2024年5月22日 · DDX21是一种多功能的RNA解旋酶，能够与多种RNA底物结合，包括R-loop等结构。 DDX21在多种生物学过程中发挥作用，其中包括RNA 聚合酶II（RNAPII）介导的转录调控。 在作者之前的研究中，已经阐明了m6A在转录终止过程中的作用，特别是5'-3'外切核酸酶XRN2的参与，这是一个关键步骤，它能够与RNAPII相互作用，促进转录RNA的释放。 如果转录过程遇到障碍，可能会导致终止缺陷，引发读穿现象，而这种情况是否会导致DNA损伤，目前还是一个 …

2014年11月24日 · Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (Pol) I and II to control multiple steps of ribosome biogenesis in human cells.

2024年4月4日 · DDX21 interacts with METTL3 for co-recruitment to chromatin through its recognition of R-loops, which can be formed co-transcriptionally as nascent transcripts hybridize onto the template DNA strand. Moreover, DDX21's helicase activity is needed for METTL3-mediated m 6 A deposition onto nascent RNA following recruitment.

Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease.

2020年6月9日 · ddx21是一类重要的dead-box rna解旋酶，兼具atp依赖的rna解旋酶活性和rna折叠酶活性。 ddx21在细胞生命周期中扮演多种重要角色，调控多种肿瘤组织的发生发展；还被报道与多种rna病毒相互作用，通过形成ddx1-ddx21-dhx36-trif复合物来作为一类重要的病毒核酸传感器。

2023年1月5日 · DDX21 localized to specific SCUGSDGC motif in mRNA introns in a glucose-dependent manner and promoted the splicing of key pro-differentiation genes, including GRHL3, KLF4, OVOL1, and RBPJ. These findings uncover a biochemical mechanism of action for glucose in modulating the dimerization and function of an RNA helicase essential for tissue ...

该基因编码一种 DEAD box 蛋白，这是一种被西瓜胃病患者的自身免疫抗体识别的抗原。 这种蛋白质解开双链 RNA，折叠单链 RNA，并可能在核糖体 RNA 生物发生、RNA 编辑、RNA 运输和一般转录中发挥重要作用。 [RefSeq 提供，2008 年 7 月] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases.

2024年5月2日 · DDX21 interacts with METTL3 for co-recruitment to chromatin through its recognition of R-loops, which can be formed co-transcriptionally as nascent transcripts hybridize onto the template DNA strand. Moreover, DDX21’s helicase activity is needed for METTL3-mediated m6A deposition onto nascent RNA following recruitment.

2020年6月8日 · RNA helicase DDX21 plays vital roles in ribosomal RNA biogenesis, transcription, and the regulation of host innate immunity during virus infection. How DDX21 recognizes and unwinds RNA and how DDX21 interacts with virus remain poorly understood. Here, crystal structures of human DDX21 determined in …