Acetylation of intrinsically disordered regions regulates phase ...
2018年12月10日 · Here, we report that IDR acetylation/deacetylation regulates LLPS and assembly of stress granules (SGs), membrane-less organelles forming in response to stress. …
Specific catalytically impaired DDX3X mutants form sexually
2024年11月5日 · Upon cellular stress, the IDRs of DDX3X (particularly its N-terminal IDR) drive it to undergo liquid-liquid phase separation (LLPS) and participate in stress granule formation, …
A comprehensive review on DDX3X liquid phase ... - ScienceDirect
2024年2月1日 · In this Review, we summarize the current understanding on the relationship among DDX3X, LLPS, and neurodevelopmental disorders (NDDs) by providing a …
Stress granule-localized USP8 potentiates cGAS-mediated type I ...
2024年6月25日 · Mechanistic study shows that the SG protein DDX3X promotes cGAS phase separation and activation in a manner dependent on its intrinsic LLPS. USP8 cleaves K27 …
Acetylation of intrinsically disordered regions regulates phase ...
The N-terminal IDR of DDX3X (IDR1) can undergo LLPS in vitro, and its acetylation at multiple lysine residues impairs the formation of liquid droplets. We also demonstrated that enhanced …
G3BP-driven RNP granules promote inhibitory RNA-RNA …
2025年2月6日 · The structure-function relationship of the IDRs in the catalytic cycle of DDX3X and its link to condensates remains to be established. However, our data indicate that the …
Cell Reports丨应激颗粒定位的 USP8 通过 DDX3X 去泛素化增强 …
Mechanistic study shows that the SG protein DDX3X promotes cGAS phase separation and activation in a manner dependent on its intrinsic LLPS. USP8 cleaves K27-linked ubiquitin …
PhaSePro - DDX3 - ELTE
The N-terminal IDR of DDX3X (IDR1) can undergo LLPS in vitro, and its acetylation at multiple lysine residues impairs the formation of liquid droplets. Enhanced LLPS propensity through …
Expanding RNA editing toolkit using an IDR-based strategy
2024年6月11日 · The CYCT1 HRD potentiated four distinct C > U editors (V1, bt1-RESCUE, 6e-RESCUE, and CURE); potentiated V1 formed puncta; distinct IDRs (DDX4, DDX3X, …
沈辉等报道RNA解旋酶DDX3X和DDX3Y的功能差异和 ... - 网易
2022年5月27日 · 他们 发现DDX3Y蛋白的N端内在无序序列 （intrinsically disordered region， IDR） 相比于DDX3X的N端内在无序序列能更强的促进其液-液相分离；DDX3Y的腺苷三磷酸酶 …