Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. [5]

Decorin能与许多细胞表面受体结合（图2），可以被认为是一种内源性、可溶性的pan-RTK抑制剂，尤其是对富含EGFR、 Met 和VEGFR2的靶细胞。 Decorin结合EGFR抑制肿瘤细胞周期和凋亡，诱导肿瘤蛋白降解并通过Met抑制血管生成。

2016年12月24日 · DCN (Decorin) is a Protein Coding gene. Diseases associated with DCN include Corneal Dystrophy, Congenital Stromal and Corneal Dystrophy . Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and …

Decorin is a multifunctional protein that plays a vital role in various biological processes. Decorin may be involved in immune-related diseases for several important reasons. First, as one of the DAMPs, it can activate pattern recognition receptors such as TLR on innate immune cells.

Decorin (DCN) is the best characterized member of the extracellular small leucine-rich proteoglycan family present in connective tissues, typically in association with or "decorating" collagen fibrils. It has substantial interest to clinical medicine owing to its antifibrotic, anti-inflammatory, and …

Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and autophagy. This functional versatility arises from a wide array of decorin/protein interactions also including interactions with its single glycosaminoglycan side chain.

Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and growth factors, particularly those that belong to the transforming growth factor–β ligand superfamily.

2025年2月15日 · Studies have shown that decorin is a potent pan-cancer tumor suppressor that is under-expressed in most cancers. Decorin interacts with receptor tyrosine kinases and functions as a pan-receptor tyrosine kinase inhibitor, thereby suppressing oncogenic signals.

Decorin抗肿瘤的 生物活性 检测，是采用MTS/PMS颜料来了解A431细胞被抑 制程度。本文从动物组织中分离、纯化得到Decorin并初步检测到其对人肺癌上 皮细胞株(A549)生长有抑制作用。

核心蛋白聚糖（decorin）是一种主要存在于 结蹄组织 中与胶原纤维相关的蛋白多糖。 它属于细胞外富含 亮氨酸 的小分子蛋白聚糖家族，由一个球形的核蛋白和一条含硫酸软骨素/硫酸皮肤素的 糖胺聚糖 （glycosaminoglycan）侧链组成的大分子糖复合物。