DECR1 participates in the beta oxidation and metabolism of polyunsaturated fatty enoyl-CoA esters. Specifically, it catalyzes the reduction of 2,4 dienoyl-CoA thioesters of varying length by NADPH cofactor to 3-trans-enoyl-CoA of equivalent length.

2024年12月24日 · DECR1 (2,4-Dienoyl-CoA Reductase 1) is a Protein Coding gene. Diseases associated with DECR1 include 2,4-Dienoyl-Coa Reductase Deficiency and Hyperlysinemia. Among its related pathways are Metabolism and Fatty acid metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADPH binding.

2,4-dienoyl-CoA reductase 1 is a protein that in humans is encoded by the DECR1 gene. [5] This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

2023年12月28日 · decr1是一种nadh依赖性的酸还原酶，它通过催化2,4-双烯酰辅酶a在β氧化过程中的还原反应来参与脂肪酸代谢。decr1的催化活性主要集中在线粒体内，作为脂肪酸β氧化途径的重要组成部分，decr1在能量代谢过程中发挥着至关重要的作用。 代谢调控中的重要作用：

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.

Our study delineates a molecular mechanism by which Decr1 potentiated higher mitochondrial lipid oxidation and cardiac damage by enhancing HADHA deacetylation through the PDK4/HDAC3 signalling pathway.

2025年3月7日 · Decr1 (2,4-dienoyl-CoA reductase 1) was found to be significantly elevated in DCM mice across the four GEO databases, emphasizing its importance in DCM pathogenesis. Consistently, the protein and mRNA expression levels of Decr1 were strikingly upregulated in the heart of diabetic rodents.

decr1 是一种负调控雄激素受体 (ar) 靶基因，因此可能促进 pca 细胞存活和对 ar 靶向治疗的耐药性。decr1敲低选择性抑制pufa的β-氧化，抑制pca细胞（包括治疗耐药细胞系）的增殖和迁移，并抑制小鼠异种移植模型中的肿瘤细胞增殖和转移。

2024年1月7日 · Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis.

关于 decr1 Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:90,001,477-90,053,633 (from NCBI) This gene has 19 transcripts (splice variants), 212 orthologues and 1 paralogue.