Defiance, MO is the gateway to Historic Missouri Wine Country. The Defiance area offers a spectacular destination for weekend retreats, weddings, history exploration, or recreation, and is a wonderful place to live.

Defiance, MO History. Missouri River. Railroads have a long history in Missouri and Defiance in particular. Railroad History. The Lewis & Clark Expedition went right past Defiance. Lewis & Clark Expedition. Daniel Boone. Daniel Boone called Defiance home, and it was his final settling place.

There are always a ton of exciting and engaging events happening in the Defiance area for families and people of all ages, year-round. Look below for a list of event calendars at a number of area establishments.

Whether you just want simple fare, or the finest dining experience, you can get it all in Defiance! Eat & Drink! The Defiance area hosts an array of dining venues from bars and restaurants to high end dining featuring renowned chefs creating distinguished eating experiences.

Some of the most beautiful and scenic parks in the St. Louis area are found around Defiance. Come visit us for hiking, biking, canoing, and other activities.

Come and visit our quaint community, stay in a B&B, a vacation rental, a "Bike & Bunk", our RV Park, or camp, and experience the history and beauty of the Defiance area. You will want to stay forever!

The Defiance - Augusta - Dutzow area hosts the first AVA district in the United States, and has a long history of producing award-winning wines. Come taste the best kept secret in the wine world, and see why our wines will keep you coming back for more!

The Defiance area contains some of the most beautiful countryside in the entire state, and some of the best parks. Come enjoy the history, wilderness and splendor of our parks while hiking, biking, and exploring.

Come find out why the Historic Missouri Wine region around Defiance has become the hottest wedding destination in the greater St. Louis area. Beautiful scenery, wonderful destinations, memorable places to stay, and exciting things to do are the reason.

Defiance has a number of shops for that special something that can add value to your visit or event. Gift shops, bike rental, shuttle services, home and garden centers, real estate assistance - it's all right here!