Dengue-specific CD8+ T cells have both protective and pathogenic roles ...
2004年9月1日 · To analyze roles of memory T cells in the pathogenesis of dengue (DEN) virus infection, a DEN virus-specific CD8 + cell clone (2D42 cell) was employed to investigate its in …
专家点评Nature｜祁海/张罗/王建斌/刘欣发现CD8 T细胞新功能、 …
2025年1月16日 · 清华大学祁海教授团队在其新发表的论文“GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases”中，发现了慢性复发性气道炎症（如慢性鼻窦 …
CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
2023年11月1日 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate …
A Protective Role for Dengue Virus-Specific CD8+ T Cells 1
2009年4月15日 · DENV infection results in a CD8 + T cell response in wild-type and IFN-α/βR −/− mice, but detectable levels of viremia only in IFN-α/βR −/− mice. A, Wild-type mice (n = 3) …
Targeted suppression of autoreactive CD8 - Nature
2016年10月17日 · We show that autoreactive CD8 + T-cells are preferentially inhibited by blocking anti-CD8 antibodies as a consequence of low affinity TCR/pMHCI interactions that …
Identification and immunogenicity of two new HLA-A*0201-restricted CD8 ...
2012年1月31日 · Identification and characterization of human CD8 + T-cell epitopes on DEN are necessary for a better understanding of the immunopathogenesis of dengue infection and …
Dengue-specific CD8 + T cells have both protective and
2004年9月1日 · Our results suggested both protective and pathogenic roles for DEN-specific CD8 + T cell in DEN virus infection, whereas NMT did not provided any protection. Dengue (DEN) …
Nature Cancer丨张泽民课题组合作发现新的人CD8+ T细胞耗竭决 …
2025年1月14日 · 为了筛选在临床病人中广泛存在的免疫逃逸的关键因素，作者使用21种肿瘤病人的单细胞转录组数据与ATAC-seq数据进行多组学分析，并通过功能性筛选，鉴定到ETV7为全 …
Dengue-specific CD8+ T cell subsets display specialized ... - PubMed
2019年3月18日 · We found that DENV-specific CD8+ T cells mainly consisted of effector memory subsets, namely CD45RA-CCR7- effector memory (Tem) and CD45RA+CCR7- effector …
CD8 - Wikipedia
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell …