DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by the DEPTOR gene. [5] The gene DEPTOR can be found only in vertebrates.

与mTORC1类似，Deptor负调节mTORC2活性，目前是mTORC2的唯一特征性内源性抑制剂。 mTORC2还有一种组件：mSIN1，属于哺乳动物应激激活的蛋白激酶相互作用蛋白。

2020年11月12日 · DEP-domain containing mTOR-interacting protein (DEPTOR), a natural mTOR inhibitor, has essential roles in several processes, including cell growth, metabolism, apoptosis, and...

2024年12月24日 · DEPTOR (DEP Domain Containing MTOR Interacting Protein) is a Protein Coding gene. Diseases associated with DEPTOR include Metaphyseal Chondrodysplasia, Jansen Type and Neurodegeneration With Brain Iron Accumulation. Among its related pathways are MAPK Signaling: Mitogens and Autophagy. An important paralog of this gene is PREX1.

2017年1月13日 · Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able to interact with mTOR and to inhibit its kinase activity. As a natural mTOR inhibitor, Deptor is involved in several molecular pathways, such as cell growth, apoptosis, autophagy and ER stress response.

2009年5月29日 · We identify DEPTOR as an mTOR-interacting protein whose expression is negatively regulated by mTORC1 and mTORC2. Loss of DEPTOR activates S6K1, Akt, and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities.

哺乳动物雷帕霉素靶蛋白 (mTOR) 是一种非典型的丝氨酸/苏氨酸激酶，存在于两个不同的复合体中。第一个为 mTOR 复合体 1 (mTORC1)，由 mTOR、Raptor、GβL 和 DEPTOR 构成，受 rapamycin 抑制。

2025年2月8日 · DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy; misregulation of the DEPTOR destruction pathway might contribute to aberrant activation of mTOR in disease. DEPTOR is a novel prognostic marker for differentiated thyroid carcinoma.

2024年12月28日 · 本文将详细介绍deptor基因的功能与作用机制，包括其在细胞中的作用、涉及的信号通路、以及与多种疾病的关系，帮助读者全面理解这一重要基因。 DEPTOR基因：细胞调控的关键角色 DEPTOR基因，全名为DEP domain containing MTOR interacting protein，位于人类染色 …

This gene has 3 transcripts (splice variants), 210 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 29.3), adrenal (RPKM 13.7) and 17 other tissues. 参与多个过程，包括 TOR 信号的负调控；细胞大小的负调节；蛋白激酶活性的负调节。 [由基因组资源联盟提供，2022 年 4 月]