Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and …
To regulate this process, deubiquitinating enzymes (DUBs) counter the signal induced by ubiquitin conjugases and ligases by removing ubiquitin from these substrates. Many DUBs selectively regulate physiological pathways employing conserved mechanisms of ubiquitin bond cleavage.
The ubiquitin system: from cell signalling to disease biology …
2021年1月14日 · Deubiquitination is performed by deubiquitinases (DUBs) that remove ubiquitin modifications from substrates. B Schematic representation and examples of some of the ubiquitin modifications...
Mechanism and function of deubiquitinating enzymes
2004年11月29日 · Polyubiquitin attachment targets many intracellular proteins for degradation by the proteasome, and (mono)ubiquitination is often required for down-regulating plasma membrane proteins by targeting them to the vacuole (lysosome). Ubiquitin–protein conjugates are highly dynamic structures.
Deubiquitinases: From mechanisms to their inhibition by small molecules
2022年1月6日 · Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in eukaryotic biology. Dysregulation of DUBs is implicated in several human diseases, highlighting the importance of DUB function.
Targeting the ubiquitination/deubiquitination process to regulate ...
2021年1月22日 · Our review will summarize the latest findings of ubiquitination/deubiquitination pathways for anti-tumor immunity, and discuss therapeutic significance of targeting...
Deubiquitinating enzymes and the proteasome regulate ... - Nature
2022年5月18日 · We uncover large dynamic ubiquitin signalling networks with substrates and sites preferentially regulated by DUBs or by the proteasome, highlighting the role of DUBs in degradation-independent...
The role of ubiquitination and deubiquitination in the regulation …
Ubiquitination is tightly regulated by ubiquitin E3 ligases and can be reversed by deubiquitinating enzymes. Recent studies have been focusing on investigating the effect of protein stability in the regulation of cell-cell junctions.
Deubiquitination | Pathway - PubChem
2019年1月17日 · Deubiquitination, the reversal of this modification, regulates the function of ubiquitin-conjugated proteins. Deubiquitinating enzymes (DUBs) catalyze the removal of Ub and regulate Ub-mediated pathways.
Histone Ubiquitination and Deubiquitination in Transcription, …
In this review, we will summarize our current understanding of histone ubiquitination and deubiquitination. In particular, we will focus on how they are regulated by histone ubiquitin ligases and deubiquitinating enzymes.
Deubiquitinating enzymes (DUBs): Regulation, homeostasis, …
2021年5月17日 · To regulate this process, deubiquitinating enzymes (DUBs) counter the signal induced by ubiquitin conjugases and ligases by removing ubiquitin from these substrates. Many DUBs selectively regulate physiological pathways employing conserved mechanisms of …
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