Chrysotile-exposed mice that receive vehicle have significant architectural changes in their lung parenchyma and large amounts of collagen deposition, whereas the lungs of the Digeranyl bisphosphonate -treated mice are essentially normal.

2015年9月1日 · By targeting the isoprenoid pathway with a novel agent, digeranyl bisphosphonate (DGBP), which impairs geranylgeranylation, we demonstrate that Rac1 mitochondrial import, mitochondrial oxidative stress, and progression of the fibrotic response to lung injury are significantly attenuated.

By targeting the isoprenoid pathway with a novel agent, digeranyl bisphosphonate (DGBP), which impairs geranylgeranylation, we demonstrate that Rac1 mitochondrial import, mitochondrial oxidative stress, and progression of the fibrotic response to lung injury are significantly attenuated.

2024年8月19日 · To further evaluate the effect of Digeranyl bisphosphonate (DGBP; 0.2 mg/kg/day) in protecting mice from chrysotile-induced pulmonary fibrosis, the mice are administered vehicle or Digeranyl bisphosphonate subcutaneously in osmotic pumps, and exposed to saline or chrysotile the following day.

To investigate the effect of Digeranyl bisphosphonate in Bleomycin-induced fibrosis, osmotic pumps containing either vehicle or Digeranyl bisphosphonate are implanted subcutaneously in WT mice. Mice are exposed to saline or Bleomycin the following day.

2013年11月15日 · To test this hypothesis, we determined the hemostatic and thrombotic effects of atorvastatin and digeranyl bisphosphonate (DGBP), a specific inhibitor of GGPP synthase, in apolipoprotein E-deficient (ApoE-/-) mice. ApoE-/- mice were treated with either vehicle, atorvastatin (50 mg/kg/d), or DGBP (0.4 mg/kg/d) subcutaneously for 7 days.

2016年9月13日 · Our novel isoprenoid bisphosphonate compounds (b) DGBP and (c) GGOHBP inhibit GGPP synthase (GGDPS), consequently reducing only GGPP and protein geranylgeranylation. In particular Rho family member Rac1 is associated clinically with PCa progression and metastasis.

2017年5月27日 · Studies performed in myeloma cells utilizing lovastatin, DGBP, or specific GGTase I or II inhibitors demonstrated that IBP inhibition induces a net increase in autophagy as a consequence of disruption of isoprenoid biosynthesis which is not recapitulated by direct geranylgeranyl transferase inhibition .

2008年7月15日 · Male mice (6–8 weeks of age) were treated with digeranyl bisphosphonate (DGBP, 0.10 mg/kg) subcutaneously three times per week for 5 weeks, after which mice were euthanized and organs were harvested for analysis. Isolation of FPP and GGPP from mouse tissues. Mice were euthanized by CO 2 overdose.