2019年4月2日 · DHODH is an enzyme that localizes to the inner mitochondrial membrane. It is the fourth and rate limiting step of the de novo pyrimidine synthesis pathway, converting dihydroorotate (DHO) to...

2024年11月7日，复旦大学附属肿瘤医院柳光宇、江一舟、龚悦等人在 Cell 子刊 Med 上发表了题为：DHDH-mediated D-xylose metabolism induces immune evasion in triple-negative breast cancer 的研究论文。 研究团队对复旦大学上海肿瘤中心三阴性乳腺癌（FUSCC TNBC）多组学数据进行生物信息分析，发现了与低免疫浸润相关的关键代谢酶二氢二醇脱氢酶（DHDH），并进一步揭示了其促进肿瘤免疫逃逸的机制。 该研究还发现，在体内补充D-木糖（DHDH的底物） …

Our findings suggest that DHODH inhibitors induce cell cycle arrest in cancer cells via additional DHODH-independent pathway that is associated with p21 up-regulation and c-Myc down-regulation. Hence, DHODH inhibitors can be explored as potential therapeutic agents in cancer therapy. Keywords: A771726, Brequinar, Ramos, DHODH shRNA, p21.

2024年11月7日，复旦大学附属肿瘤医院柳光宇、江一舟、龚悦等人在 Cell 子刊 Med 上发表了题为：DHDH-mediated D-xylose metabolism induces immune evasion in triple-negative breast cancer 的研究论文。 研究团队对复旦大学上海肿瘤中心三阴性乳腺癌（FUSCC TNBC）多组学数据进行生物信息分析，发现了与低免疫浸润相关的关键代谢酶二氢二醇脱氢酶（DHDH），并进一步揭示了其促进肿瘤免疫逃逸的机制。 该研究还发现，在体内补充D-木糖（DHDH的底物） …

Dihydroorotate dehydrogenase (DHODH) is a ubiquitous enzyme located within the inner membrane of the mitochondria. Using the cofactor ubiquinone, DHODH catalyzes the fourth step of de novo pyrimidine synthesis: the conversion of dihydroorotate to orotate.

2017年1月13日 · We developed an assay method for measuring dihydroorotate dehydrogenase (DHODH) activity in cultured HeLa cells and fibroblasts, and in stage III stomach cancer and adjacent normal tissues from the...

2019年3月1日 · DHODH is a druggable enzyme that plays a vital role in the metabolism of cancer cells. DHODH catalyzes the oxidation of dihydroorotate to orotate, which is essential for the production of uridine monophosphate (UMP) (Munier, Vidalain, Tangy, & Janin, 2013; Reis, Calil, Feliciano, Pinheiro, & Nonato, 2017; Vyas & Ghate, 2011).

2020年6月1日 · Here we discuss the role of DHODH in the oxidative phosphorylation system and in the initiation and progression of cancer. We summarize recent findings on DHODH biology, the progress made in the development of new, specific inhibitors of DHODH intended for cancer therapy, and the mechanistic insights into the consequences of DHODH inhibition.

2021年8月30日 · Here we report that the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is an attractive therapeutic target for MYCN -amplified neuroblastoma, a childhood cancer with poor...

该基因编码一种属于二氢二醇脱氢酶家族的酶，该酶以多种形式存在于哺乳动物组织中，并参与外源物质和糖类的代谢。 这些酶催化 NADP1 连接的芳烃反式二氢二醇氧化成相应的儿茶酚。 该酶是一种二聚二氢二醇脱氢酶，它与单体二氢二醇脱氢酶的不同之处在于它在氧化方向上对芳烃的反式二氢二醇具有高底物特异性。 [RefSeq 提供，2008 年 7 月]